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Population-specific polygenic risk scores for people of Han Chinese ancestry.

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Title: Population-specific polygenic risk scores for people of Han Chinese ancestry.
Authors: Chen HH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. hunghsinchen@ibms.sinica.edu.tw.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. hunghsinchen@ibms.sinica.edu.tw., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Hou MC; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Fu YC; Department of Pediatric Cardiology, Taichung Veterans General Hospital, Taichung, Taiwan.; Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Pediatrics, School of Medicine, National Chung-Hsing University, Taichung, Taiwan., Li LH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chou CY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Yeh EC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Tsai MF; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan., Yang HC; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan., Huang YT; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.; Department of Mathematics, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan., Liu YM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Wei CY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Core Laboratory of Neoantigen Analysis for Personalized Cancer Vaccine, Office of R&D, Taipei Medical University, Taipei, Taiwan., Su JP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lin WJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Wang EHF; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chiang CL; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Jiang JK; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan., Lee IH; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan., Liang KH; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Biomedical Informatics, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen WS; Division of Allergy, Immunology & Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai HC; Division of Allergy, Immunology & Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lin SY; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Chang FP; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Ho HL; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Yeh YC; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Tseng WC; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lin MH; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Chang HT; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Tseng LM; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.; Comprehensive Breast Health Center, Taipei Veterans General Hospital, Taipei, Taiwan., Liang WY; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Chen PC; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Hsieh YC; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Medical Research, Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen YM; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan., Hsiao TH; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Lin CH; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chen YJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chen IC; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Mao CL; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chang SJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chang YL; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan., Liao YJ; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan., Lai CH; Department of Medicine and Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan., Lee WJ; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan., Tung H; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan., Yen TT; Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan., Yen HC; Division of Pediatric Genetics and Metabolism, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan., Chen MY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan., Lin YC; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Occupational Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Kao YT; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan., Kao BZ; Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan., Lee JE; Department of Neurology, Wan Fang Hospital and Taipei Medical University, Taipei, Taiwan., Chung CL; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan., Liu JC; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan., Chan P; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Lin CH; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chen CH; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Wu IC; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan., Lin LC; Departments of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Wang JW; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Shih SL; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Medical Education and Humanizing Health Professional Education, Kaohsiung Medical University, Kaohsiung, Taiwan., Hsieh SW; Department of Neurology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Hung CH; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan., Li WM; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan., Yang CJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Yang CS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Weng RH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chang CP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Wu TH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lin YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Sheen YJ; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Wang SH; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan., Chen SP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Raben T; Michigan State University, East Lansing, MI, USA., Widen E; Michigan State University, East Lansing, MI, USA.; Genomic Prediction, Inc., Hackettstown, NJ, USA., Hsu S; Michigan State University, East Lansing, MI, USA.; Genomic Prediction, Inc., Hackettstown, NJ, USA., Hsieh FJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA., Ho DR; Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan., Huang YH; Department of Dermatology, Chang Gung Memorial Hopistal, Linkou, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan, Taiwan., Yang CH; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Huang YS; Department of Psychiatry and Sleep center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chen YF; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Wu HM; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan., Tsai PH; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, New Taipei City Municipal TuCheng Hospital, New Taipei City, Taiwan., Huang KG; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan., Chien CY; Department of Otolaryngology Head & Neck Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Doctoral Program of Clinical and Experimental Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan., Ho YL; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Wu MS; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Kao JH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Liu YB; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Juang JJ; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Cardiovascular Center and Heart Failure Center, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lin MH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Lin YH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan., Lee JY; Department of Internal Medicine, National Taiwan University Hospital Yunlin branch, Yunlin, Taiwan., Lu HJ; Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Lu CH; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Feng AC; General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Liu JS; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Chiang CP; Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.; Department and Graduate Institute of Biochemistry, National Defense Medical Center, Taipei, Taiwan., Chu NF; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Lin JC; Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Yeh YW; Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Meng E; Urology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Huang CY; Cardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan., Li CC; Center of Stem Cell and Precision Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan.; Department of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Wang TF; Department of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan.; Buddhist Tzu Chi Stem Cells Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Su KY; School of Medicine, Tzu Chi University, Hualien, Taiwan.; Division of Allergy, Immunology and Rheumatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Wang JK; Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.; Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Medicine, National Taiwan University, Taipei, Taiwan., Chen MH; Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.; Department of Biomedical Engineering, Ming Chuan University, Taoyuan, Taiwan., Chen HF; Division of Endocrinology, Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.; Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan., Ma GC; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan., Chang TY; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan., Chiang FT; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.; Department of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan., Chang HJ; Precision Medicine Center, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.; Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, New Taipei City, Taiwan., Kao KJ; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan., Hung CF; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan., Tsai CY; Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan.; Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Health and Welfare, University of Taipei, Taipei, Taiwan., Chen PY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.; Clinical Trial Center, Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan., Tsui K; Fu-Jen Catholic University School of Medicine, New Taipei City, Taiwan.; Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.; Department of Clinical Pathology, Cathay General Hospital, Taipei, Taiwan., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Kwok PY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, CA, USA.; Department of Dermatology, University of California, San Francisco, CA, USA., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan., Liou JM; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan., Wang JY; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Chiou JF; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Fann CSJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. csjfann@ibms.sinica.edu.tw.
Source: Nature [Nature] 2025 Dec; Vol. 648 (8092), pp. 128-137. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
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  Group: Ti
  Data: Population-specific polygenic risk scores for people of Han Chinese ancestry.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. hunghsinchen@ibms.sinica.edu.tw.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. hunghsinchen@ibms.sinica.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hou+MC%22">Hou MC</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fu+YC%22">Fu YC</searchLink>; Department of Pediatric Cardiology, Taichung Veterans General Hospital, Taichung, Taiwan.; Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Pediatrics, School of Medicine, National Chung-Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+LH%22">Li LH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+CY%22">Chou CY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+EC%22">Yeh EC</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MF%22">Tsai MF</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+HC%22">Yang HC</searchLink>; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YT%22">Huang YT</searchLink>; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.; Department of Mathematics, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YM%22">Liu YM</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wei+CY%22">Wei CY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Core Laboratory of Neoantigen Analysis for Personalized Cancer Vaccine, Office of R&D, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+JP%22">Su JP</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+WJ%22">Lin WJ</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+EHF%22">Wang EHF</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+CL%22">Chiang CL</searchLink>; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+JK%22">Jiang JK</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+IH%22">Lee IH</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liang+KH%22">Liang KH</searchLink>; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Biomedical Informatics, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WS%22">Chen WS</searchLink>; Division of Allergy, Immunology & Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+HC%22">Tsai HC</searchLink>; Division of Allergy, Immunology & Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SY%22">Lin SY</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+FP%22">Chang FP</searchLink>; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+HL%22">Ho HL</searchLink>; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+YC%22">Yeh YC</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+WC%22">Tseng WC</searchLink>; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+MH%22">Lin MH</searchLink>; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+HT%22">Chang HT</searchLink>; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+LM%22">Tseng LM</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.; Comprehensive Breast Health Center, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liang+WY%22">Liang WY</searchLink>; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PC%22">Chen PC</searchLink>; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YC%22">Hsieh YC</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Medical Research, Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YM%22">Chen YM</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+TH%22">Hsiao TH</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+IC%22">Chen IC</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Mao+CL%22">Mao CL</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+SJ%22">Chang SJ</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+YL%22">Chang YL</searchLink>; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+YJ%22">Liao YJ</searchLink>; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+CH%22">Lai CH</searchLink>; Department of Medicine and Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+WJ%22">Lee WJ</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tung+H%22">Tung H</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+TT%22">Yen TT</searchLink>; Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+HC%22">Yen HC</searchLink>; Division of Pediatric Genetics and Metabolism, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+MY%22">Chen MY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YC%22">Lin YC</searchLink>; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Occupational Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+YT%22">Kao YT</searchLink>; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+BZ%22">Kao BZ</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+JE%22">Lee JE</searchLink>; Department of Neurology, Wan Fang Hospital and Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chung+CL%22">Chung CL</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+JC%22">Liu JC</searchLink>; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chan+P%22">Chan P</searchLink>; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+IC%22">Wu IC</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+LC%22">Lin LC</searchLink>; Departments of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JW%22">Wang JW</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shih+SL%22">Shih SL</searchLink>; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Medical Education and Humanizing Health Professional Education, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+SW%22">Hsieh SW</searchLink>; Department of Neurology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+CH%22">Hung CH</searchLink>; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+WM%22">Li WM</searchLink>; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+CJ%22">Yang CJ</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+CS%22">Yang CS</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Weng+RH%22">Weng RH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CP%22">Chang CP</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+TH%22">Wu TH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YC%22">Lin YC</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sheen+YJ%22">Sheen YJ</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+SH%22">Wang SH</searchLink>; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SP%22">Chen SP</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Raben+T%22">Raben T</searchLink>; Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22Widen+E%22">Widen E</searchLink>; Michigan State University, East Lansing, MI, USA.; Genomic Prediction, Inc., Hackettstown, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+S%22">Hsu S</searchLink>; Michigan State University, East Lansing, MI, USA.; Genomic Prediction, Inc., Hackettstown, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hsieh+FJ%22">Hsieh FJ</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ho+DR%22">Ho DR</searchLink>; Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YH%22">Huang YH</searchLink>; Department of Dermatology, Chang Gung Memorial Hopistal, Linkou, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+CH%22">Yang CH</searchLink>; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YS%22">Huang YS</searchLink>; Department of Psychiatry and Sleep center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YF%22">Chen YF</searchLink>; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+HM%22">Wu HM</searchLink>; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+PH%22">Tsai PH</searchLink>; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, New Taipei City Municipal TuCheng Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KG%22">Huang KG</searchLink>; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+CY%22">Chien CY</searchLink>; Department of Otolaryngology Head & Neck Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Doctoral Program of Clinical and Experimental Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+YL%22">Ho YL</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+MS%22">Wu MS</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+JH%22">Kao JH</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YB%22">Liu YB</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Juang+JJ%22">Juang JJ</searchLink>; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Cardiovascular Center and Heart Failure Center, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+MH%22">Lin MH</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Department of Internal Medicine, National Taiwan University Hospital Yunlin branch, Yunlin, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+HJ%22">Lu HJ</searchLink>; Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+CH%22">Lu CH</searchLink>; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Feng+AC%22">Feng AC</searchLink>; General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+JS%22">Liu JS</searchLink>; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+CP%22">Chiang CP</searchLink>; Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.; Department and Graduate Institute of Biochemistry, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+NF%22">Chu NF</searchLink>; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+YW%22">Yeh YW</searchLink>; Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Meng+E%22">Meng E</searchLink>; Urology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CY%22">Huang CY</searchLink>; Cardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+CC%22">Li CC</searchLink>; Center of Stem Cell and Precision Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan.; Department of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+TF%22">Wang TF</searchLink>; Department of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan.; Buddhist Tzu Chi Stem Cells Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+KY%22">Su KY</searchLink>; School of Medicine, Tzu Chi University, Hualien, Taiwan.; Division of Allergy, Immunology and Rheumatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JK%22">Wang JK</searchLink>; Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.; Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+MH%22">Chen MH</searchLink>; Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.; Department of Biomedical Engineering, Ming Chuan University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+HF%22">Chen HF</searchLink>; Division of Endocrinology, Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.; Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ma+GC%22">Ma GC</searchLink>; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+TY%22">Chang TY</searchLink>; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+FT%22">Chiang FT</searchLink>; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.; Department of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+HJ%22">Chang HJ</searchLink>; Precision Medicine Center, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.; Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+KJ%22">Kao KJ</searchLink>; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+CF%22">Hung CF</searchLink>; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CY%22">Tsai CY</searchLink>; Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan.; Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Health and Welfare, University of Taipei, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PY%22">Chen PY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.; Clinical Trial Center, Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsui+K%22">Tsui K</searchLink>; Fu-Jen Catholic University School of Medicine, New Taipei City, Taiwan.; Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.; Department of Clinical Pathology, Cathay General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YT%22">Chen YT</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kwok+PY%22">Kwok PY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, CA, USA.; Department of Dermatology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sheu+WH%22">Sheu WH</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+SF%22">Yang SF</searchLink>; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liou+JM%22">Liou JM</searchLink>; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JY%22">Wang JY</searchLink>; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+JF%22">Chiou JF</searchLink>; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+JY%22">Wu JY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fann+CSJ%22">Fann CSJ</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. csjfann@ibms.sinica.edu.tw.
– Name: TitleSource
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 Dec; Vol. 648 (8092), pp. 128-137. <i>Date of Electronic Publication: </i>2025 Oct 15.
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  Data: Journal Article
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE
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      – TitleFull: Population-specific polygenic risk scores for people of Han Chinese ancestry.
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            NameFull: Chen WS
      – PersonEntity:
          Name:
            NameFull: Tsai HC
      – PersonEntity:
          Name:
            NameFull: Lin SY
      – PersonEntity:
          Name:
            NameFull: Chang FP
      – PersonEntity:
          Name:
            NameFull: Ho HL
      – PersonEntity:
          Name:
            NameFull: Yeh YC
      – PersonEntity:
          Name:
            NameFull: Tseng WC
      – PersonEntity:
          Name:
            NameFull: Lin MH
      – PersonEntity:
          Name:
            NameFull: Chang HT
      – PersonEntity:
          Name:
            NameFull: Tseng LM
      – PersonEntity:
          Name:
            NameFull: Liang WY
      – PersonEntity:
          Name:
            NameFull: Chen PC
      – PersonEntity:
          Name:
            NameFull: Hsieh YC
      – PersonEntity:
          Name:
            NameFull: Chen YM
      – PersonEntity:
          Name:
            NameFull: Hsiao TH
      – PersonEntity:
          Name:
            NameFull: Lin CH
      – PersonEntity:
          Name:
            NameFull: Chen YJ
      – PersonEntity:
          Name:
            NameFull: Chen IC
      – PersonEntity:
          Name:
            NameFull: Mao CL
      – PersonEntity:
          Name:
            NameFull: Chang SJ
      – PersonEntity:
          Name:
            NameFull: Chang YL
      – PersonEntity:
          Name:
            NameFull: Liao YJ
      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
            NameFull: Lee WJ
      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
            NameFull: Liu JC
      – PersonEntity:
          Name:
            NameFull: Chan P
      – PersonEntity:
          Name:
            NameFull: Lin CH
      – PersonEntity:
          Name:
            NameFull: Chen CH
      – PersonEntity:
          Name:
            NameFull: Wu IC
      – PersonEntity:
          Name:
            NameFull: Lin LC
      – PersonEntity:
          Name:
            NameFull: Wang JW
      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
            NameFull: Hung CH
      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
            NameFull: Chien CY
      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
            NameFull: Kao JH
      – PersonEntity:
          Name:
            NameFull: Liu YB
      – PersonEntity:
          Name:
            NameFull: Juang JJ
      – PersonEntity:
          Name:
            NameFull: Lin MH
      – PersonEntity:
          Name:
            NameFull: Lin YH
      – PersonEntity:
          Name:
            NameFull: Lee JY
      – PersonEntity:
          Name:
            NameFull: Lu HJ
      – PersonEntity:
          Name:
            NameFull: Lu CH
      – PersonEntity:
          Name:
            NameFull: Feng AC
      – PersonEntity:
          Name:
            NameFull: Liu JS
      – PersonEntity:
          Name:
            NameFull: Chiang CP
      – PersonEntity:
          Name:
            NameFull: Chu NF
      – PersonEntity:
          Name:
            NameFull: Lin JC
      – PersonEntity:
          Name:
            NameFull: Yeh YW
      – PersonEntity:
          Name:
            NameFull: Meng E
      – PersonEntity:
          Name:
            NameFull: Huang CY
      – PersonEntity:
          Name:
            NameFull: Li CC
      – PersonEntity:
          Name:
            NameFull: Wang TF
      – PersonEntity:
          Name:
            NameFull: Su KY
      – PersonEntity:
          Name:
            NameFull: Wang JK
      – PersonEntity:
          Name:
            NameFull: Chen MH
      – PersonEntity:
          Name:
            NameFull: Chen HF
      – PersonEntity:
          Name:
            NameFull: Ma GC
      – PersonEntity:
          Name:
            NameFull: Chang TY
      – PersonEntity:
          Name:
            NameFull: Chiang FT
      – PersonEntity:
          Name:
            NameFull: Chang HJ
      – PersonEntity:
          Name:
            NameFull: Kao KJ
      – PersonEntity:
          Name:
            NameFull: Hung CF
      – PersonEntity:
          Name:
            NameFull: Tsai CY
      – PersonEntity:
          Name:
            NameFull: Chen PY
      – PersonEntity:
          Name:
            NameFull: Tsui K
      – PersonEntity:
          Name:
            NameFull: Chen YT
      – PersonEntity:
          Name:
            NameFull: Kwok PY
      – PersonEntity:
          Name:
            NameFull: Sheu WH
      – PersonEntity:
          Name:
            NameFull: Yang SF
      – PersonEntity:
          Name:
            NameFull: Liou JM
      – PersonEntity:
          Name:
            NameFull: Wang JY
      – PersonEntity:
          Name:
            NameFull: Chiou JF
      – PersonEntity:
          Name:
            NameFull: Wu JY
      – PersonEntity:
          Name:
            NameFull: Fann CSJ
    IsPartOfRelationships:
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          Dates:
            – D: 01
              M: 12
              Text: 2025 Dec
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 648
            – Type: issue
              Value: 8092
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1