Computational chemistry-based structure-guiding engineering of ω-transaminases to enhance catalytic activity and enantioselectivity toward bulky ketones.
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| Title: | Computational chemistry-based structure-guiding engineering of ω-transaminases to enhance catalytic activity and enantioselectivity toward bulky ketones. |
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| Authors: | Li Z; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China., Wang Y; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China., Huang K; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China., Lu Q; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. Electronic address: luqun1125@home.swjtu.edu.cn., Tian F; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. Electronic address: tulwar@home.swjtu.edu.cn. |
| Source: | International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 331 (Pt 1), pp. 148070. Date of Electronic Publication: 2025 Oct 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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