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Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis.

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Title: Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis.
Authors: O'Neill A; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Zakaria N; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Bull C; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Egan H; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Corry SM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK., Leonard NA; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., O'Meara C; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Howard L; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., Walsh A; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Reidy E; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; CÚRAM Centre for Research in Medical Devices, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Che J; Palleon Pharmaceuticals, Waltham, MA 02451, USA., Peng L; Palleon Pharmaceuticals, Waltham, MA 02451, USA., Cao L; Palleon Pharmaceuticals, Waltham, MA 02451, USA., Egan LJ; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Ritter T; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; CÚRAM Centre for Research in Medical Devices, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Sheehan M; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland., Canney A; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland., Culligan K; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland., Hogan AM; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Department of Colorectal Surgery, Galway University Hospital, Galway, Ireland., Hynes SO; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland.; Discipline of Pathology, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Dunne PD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Cancer Research UK Scotland Institute, Glasgow, UK., O'Dwyer M; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Discipline of Medicine, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Treacy O; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Ryan AE; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland aideen.ryan@universityofgalway.ie.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; CÚRAM Centre for Research in Medical Devices, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Oct 19; Vol. 13 (10). Date of Electronic Publication: 2025 Oct 19.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
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  Data: Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis.
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Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Reidy+E%22">Reidy E</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; CÚRAM Centre for Research in Medical Devices, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Che+J%22">Che J</searchLink>; 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Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Canney+A%22">Canney A</searchLink>; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Culligan+K%22">Culligan K</searchLink>; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Hogan+AM%22">Hogan AM</searchLink>; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Department of Colorectal Surgery, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Hynes+SO%22">Hynes SO</searchLink>; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland.; Discipline of Pathology, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Dunne+PD%22">Dunne PD</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Cancer Research UK Scotland Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22O'Dwyer+M%22">O'Dwyer M</searchLink>; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Discipline of Medicine, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Treacy+O%22">Treacy O</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Ryan+AE%22">Ryan AE</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland aideen.ryan@universityofgalway.ie.; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; CÚRAM Centre for Research in Medical Devices, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.
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