Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential.
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| Title: | Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential. |
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| Authors: | Puigseslloses P; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Nadal-Gratacós N; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain., Fumàs B; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain., Modenutti CP; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), C1428EHA, Ciudad de Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, C1428EHA, Ciudad de Buenos Aires, Argentina.; Istituto di Biologia e Biotecnologia Agraria (IBBA), Consiglio Nazionale della Ricerca (CNR), Via Alfonso Corti nr. 12, I-20133, Milano, Italia., Pottie E; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium., Ortigosa JR; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), C1428EHA, Ciudad de Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, C1428EHA, Ciudad de Buenos Aires, Argentina., Pablo-Quesada A; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Riera-Colomer C; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain., Ettcheto M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Av. Josep Laporte, 2, 43204, Reus, Spain., Berzosa X; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Pubill D; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain., Stove C; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium., Escubedo E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain., López-Arnau R; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu. |
| Source: | Molecular psychiatry [Mol Psychiatry] 2026 Mar; Vol. 31 (3), pp. 1733-1745. Date of Electronic Publication: 2025 Oct 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41120735 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Puigseslloses+P%22">Puigseslloses P</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nadal-Gratacós+N%22">Nadal-Gratacós N</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fumàs+B%22">Fumàs B</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Modenutti+CP%22">Modenutti CP</searchLink>; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), C1428EHA, Ciudad de Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, C1428EHA, Ciudad de Buenos Aires, Argentina.; Istituto di Biologia e Biotecnologia Agraria (IBBA), Consiglio Nazionale della Ricerca (CNR), Via Alfonso Corti nr. 12, I-20133, Milano, Italia.<br /><searchLink fieldCode="AU" term="%22Pottie+E%22">Pottie E</searchLink>; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Ortigosa+JR%22">Ortigosa JR</searchLink>; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), C1428EHA, Ciudad de Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, C1428EHA, Ciudad de Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Pablo-Quesada+A%22">Pablo-Quesada A</searchLink>; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Riera-Colomer+C%22">Riera-Colomer C</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ettcheto+M%22">Ettcheto M</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Av. Josep Laporte, 2, 43204, Reus, Spain.<br /><searchLink fieldCode="AU" term="%22Berzosa+X%22">Berzosa X</searchLink>; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pubill+D%22">Pubill D</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Stove+C%22">Stove C</searchLink>; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Escubedo+E%22">Escubedo E</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22López-Arnau+R%22">López-Arnau R</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2026 Mar; Vol. 31 (3), pp. 1733-1745. <i>Date of Electronic Publication: </i>2025 Oct 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41380-025-03308-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1733 Titles: – TitleFull: Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Puigseslloses P – PersonEntity: Name: NameFull: Nadal-Gratacós N – PersonEntity: Name: NameFull: Fumàs B – PersonEntity: Name: NameFull: Modenutti CP – PersonEntity: Name: NameFull: Pottie E – PersonEntity: Name: NameFull: Ortigosa JR – PersonEntity: Name: NameFull: Pablo-Quesada A – PersonEntity: Name: NameFull: Riera-Colomer C – PersonEntity: Name: NameFull: Ettcheto M – PersonEntity: Name: NameFull: Berzosa X – PersonEntity: Name: NameFull: Pubill D – PersonEntity: Name: NameFull: Stove C – PersonEntity: Name: NameFull: Escubedo E – PersonEntity: Name: NameFull: López-Arnau R IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1476-5578 Numbering: – Type: volume Value: 31 – Type: issue Value: 3 Titles: – TitleFull: Molecular psychiatry Type: main |
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