Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential.
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| Title: | Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential. |
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| Authors: | Puigseslloses P; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Nadal-Gratacós N; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain., Fumàs B; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain., Modenutti CP; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), C1428EHA, Ciudad de Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, C1428EHA, Ciudad de Buenos Aires, Argentina.; Istituto di Biologia e Biotecnologia Agraria (IBBA), Consiglio Nazionale della Ricerca (CNR), Via Alfonso Corti nr. 12, I-20133, Milano, Italia., Pottie E; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium., Ortigosa JR; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), C1428EHA, Ciudad de Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, C1428EHA, Ciudad de Buenos Aires, Argentina., Pablo-Quesada A; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Riera-Colomer C; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain., Ettcheto M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Av. Josep Laporte, 2, 43204, Reus, Spain., Berzosa X; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Pubill D; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain., Stove C; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium., Escubedo E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain., López-Arnau R; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu. |
| Source: | Molecular psychiatry [Mol Psychiatry] 2026 Mar; Vol. 31 (3), pp. 1733-1745. Date of Electronic Publication: 2025 Oct 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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