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SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade.

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Title: SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade.
Authors: Grippin AJ; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. agrippin@mdanderson.org., Marconi C; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Copling S; McGovern Medical School, Houston, TX, USA., Li N; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Braun C; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Woody C; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Young E; Department of Enterprise Data Engineering and Analytics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gupta P; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang M; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wu A; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jeong SD; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Soni D; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Weidert F; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Xie C; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Goldenberg E; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Kim A; McGovern Medical School, Houston, TX, USA., Zhao C; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., DeVries A; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Castillo P; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.; Department of Pediatrics, Division of Hematology-Oncology, University of Florida, Gainesville, FL, USA., Lohray R; Department of Dermatology, Baylor College of Medicine, Houston, TX, USA., Rooney MK; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Schrank BR; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang Y; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ma Y; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang E; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kouzy R; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dyson K; Department of Pathology, Stanford University, Stanford, CA, USA., Jafarnia J; McGovern Medical School, Houston, TX, USA., Nariman N; McGovern Medical School, Houston, TX, USA., Gladish G; Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., New J; Scripps Health, San Diego, CA, USA., Argueta A; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Amaya D; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Thomas N; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Doty A; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Chen J; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Copling N; University of North Carolina, Chapel Hill, NC, USA., Alatrash G; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Simon J; Department of Surgical Oncology, Division Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Davies AB; Department of Surgical Oncology, Division Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dennis W; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liang R; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lewis J; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wei X; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rinsurongkawong W; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vaporciyan AA; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Johns A; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee J; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee JH; Department of Biostatistics, The University of Florida, Gainesville, FL, USA., Sun R; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sharma P; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tran H; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang J; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gibbons DL; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wargo J; Department of Surgical Oncology, Division Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kim BYS; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heymach JV; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mendez-Gomez HR; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Jiang W; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sayour EJ; Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. elias.sayour@neurosurgery.ufl.edu.; Department of Pediatrics, Division of Hematology-Oncology, University of Florida, Gainesville, FL, USA. elias.sayour@neurosurgery.ufl.edu., Lin SH; Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. shlin@mdanderson.org.
Corporate Authors: D3CODE Team
Source: Nature [Nature] 2025 Nov; Vol. 647 (8089), pp. 488-497. Date of Electronic Publication: 2025 Oct 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade.
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          Name:
            NameFull: Thomas N
      – PersonEntity:
          Name:
            NameFull: Doty A
      – PersonEntity:
          Name:
            NameFull: Chen J
      – PersonEntity:
          Name:
            NameFull: Copling N
      – PersonEntity:
          Name:
            NameFull: Alatrash G
      – PersonEntity:
          Name:
            NameFull: Simon J
      – PersonEntity:
          Name:
            NameFull: Davies AB
      – PersonEntity:
          Name:
            NameFull: Dennis W
      – PersonEntity:
          Name:
            NameFull: Liang R
      – PersonEntity:
          Name:
            NameFull: Lewis J
      – PersonEntity:
          Name:
            NameFull: Wei X
      – PersonEntity:
          Name:
            NameFull: Rinsurongkawong W
      – PersonEntity:
          Name:
            NameFull: Vaporciyan AA
      – PersonEntity:
          Name:
            NameFull: Johns A
      – PersonEntity:
          Name:
            NameFull: Lee J
      – PersonEntity:
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      – PersonEntity:
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            NameFull: Mendez-Gomez HR
      – PersonEntity:
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            NameFull: Jiang W
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          Dates:
            – D: 01
              M: 11
              Text: 2025 Nov
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 647
            – Type: issue
              Value: 8089
          Titles:
            – TitleFull: Nature
              Type: main
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