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Intraoperative cell-salvaged versus allogeneic red blood cell transfusions in high-bleeding-risk cardiovascular surgery: Protocol for a single-center, randomized, parallel-group, noninferiority trial.

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Title: Intraoperative cell-salvaged versus allogeneic red blood cell transfusions in high-bleeding-risk cardiovascular surgery: Protocol for a single-center, randomized, parallel-group, noninferiority trial.
Authors: Tsukinaga A; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.; Department of Transfusion, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Yoshitani K; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.; Department of Transfusion, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Ogata S; Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Mihara T; Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Kanagawa, Japan.; Department of Anesthesiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan., Ito S; Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Kanazawa H; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Shimokawa A; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Masuda S; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Morinaga M; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Ito Y; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Miura S; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Kawamoto N; Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Inoue Y; Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Fukushima S; Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Matsuda H; Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan., Maeda T; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Source: PloS one [PLoS One] 2025 Oct 24; Vol. 20 (10), pp. e0334397. Date of Electronic Publication: 2025 Oct 24 (Print Publication: 2025).
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intraoperative cell-salvaged versus allogeneic red blood cell transfusions in high-bleeding-risk cardiovascular surgery: Protocol for a single-center, randomized, parallel-group, noninferiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Tsukinaga+A%22">Tsukinaga A</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.; Department of Transfusion, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshitani+K%22">Yoshitani K</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.; Department of Transfusion, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ogata+S%22">Ogata S</searchLink>; Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Mihara+T%22">Mihara T</searchLink>; Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Kanagawa, Japan.; Department of Anesthesiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+S%22">Ito S</searchLink>; Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kanazawa+H%22">Kanazawa H</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Shimokawa+A%22">Shimokawa A</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Masuda+S%22">Masuda S</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Morinaga+M%22">Morinaga M</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+Y%22">Ito Y</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Miura+S%22">Miura S</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kawamoto+N%22">Kawamoto N</searchLink>; Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+Y%22">Inoue Y</searchLink>; Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Fukushima+S%22">Fukushima S</searchLink>; Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuda+H%22">Matsuda H</searchLink>; Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Maeda+T%22">Maeda T</searchLink>; Department of Anesthesiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2025 Oct 24; Vol. 20 (10), pp. e0334397. <i>Date of Electronic Publication: </i>2025 Oct 24 (<i>Print Publication: </i>2025).
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