Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.

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Title: Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.
Authors: Mallard TT; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston., Tubbs JD; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston., Jennings M; Department of Psychiatry, University of California San Diego, La Jolla., Zhang Y; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston., Gustavson DE; Institute for Behavioral Genetics, University of Colorado Boulder., Grotzinger AD; Institute for Behavioral Genetics, University of Colorado Boulder.; Department of Psychology and Neuroscience, University of Colorado Boulder., Westwater ML; Department of Psychiatry, University of Oxford, Oxford, UK., Williams CM; Population Research Center, University of Texas at Austin., Fortgang RG; Department of Psychiatry, Harvard Medical School, Boston.; Population Research Center, University of Texas at Austin., Elson SL; 23andMe, Inc., Sunnyvale, CA., Fontanillas P; 23andMe, Inc., Sunnyvale, CA., Davis LK; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN., Raznahan A; Section on Developmental Neurogenomics, NIMH, Bethesda, MD., Tucker-Drob EM; Population Research Center, University of Texas at Austin.; Department of Psychology, University of Texas at Austin., Choi KW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston., Ge T; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston., Smoller JW; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla.; Institute for Genomic Medicine, University of California San Diego, La Jolla., Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Institute for Genomic Medicine, University of California San Diego, La Jolla.
Source: The American journal of psychiatry [Am J Psychiatry] 2026 Jan 01; Vol. 183 (1), pp. 31-47. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article
Journal Info: Publisher: American Psychiatric Association Country of Publication: United States NLM ID: 0370512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7228 (Electronic) Linking ISSN: 0002953X NLM ISO Abbreviation: Am J Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mallard+TT%22">Mallard TT</searchLink>; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston.<br /><searchLink fieldCode="AU" term="%22Tubbs+JD%22">Tubbs JD</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston.<br /><searchLink fieldCode="AU" term="%22Jennings+M%22">Jennings M</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston.<br /><searchLink fieldCode="AU" term="%22Gustavson+DE%22">Gustavson DE</searchLink>; Institute for Behavioral Genetics, University of Colorado Boulder.<br /><searchLink fieldCode="AU" term="%22Grotzinger+AD%22">Grotzinger AD</searchLink>; Institute for Behavioral Genetics, University of Colorado Boulder.; Department of Psychology and Neuroscience, University of Colorado Boulder.<br /><searchLink fieldCode="AU" term="%22Westwater+ML%22">Westwater ML</searchLink>; Department of Psychiatry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Williams+CM%22">Williams CM</searchLink>; Population Research Center, University of Texas at Austin.<br /><searchLink fieldCode="AU" term="%22Fortgang+RG%22">Fortgang RG</searchLink>; Department of Psychiatry, Harvard Medical School, Boston.; Population Research Center, University of Texas at Austin.<br /><searchLink fieldCode="AU" term="%22Elson+SL%22">Elson SL</searchLink>; 23andMe, Inc., Sunnyvale, CA.<br /><searchLink fieldCode="AU" term="%22Fontanillas+P%22">Fontanillas P</searchLink>; 23andMe, Inc., Sunnyvale, CA.<br /><searchLink fieldCode="AU" term="%22Davis+LK%22">Davis LK</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Raznahan+A%22">Raznahan A</searchLink>; Section on Developmental Neurogenomics, NIMH, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Tucker-Drob+EM%22">Tucker-Drob EM</searchLink>; Population Research Center, University of Texas at Austin.; Department of Psychology, University of Texas at Austin.<br /><searchLink fieldCode="AU" term="%22Choi+KW%22">Choi KW</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston.<br /><searchLink fieldCode="AU" term="%22Ge+T%22">Ge T</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston.<br /><searchLink fieldCode="AU" term="%22Smoller+JW%22">Smoller JW</searchLink>; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston.; Department of Psychiatry, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Boston.<br /><searchLink fieldCode="AU" term="%22Palmer+AA%22">Palmer AA</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla.; Institute for Genomic Medicine, University of California San Diego, La Jolla.<br /><searchLink fieldCode="AU" term="%22Sanchez-Roige+S%22">Sanchez-Roige S</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Institute for Genomic Medicine, University of California San Diego, La Jolla.
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