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Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor.

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Title: Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor.
Authors: Suno-Ikeda C; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan., Nishikawa R; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan., Suzuki R; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Yokoi S; Department of Physics, School of Science and Technology, Meiji University, Kawasaki, Kanagawa, Japan.; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan., Iwata S; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan., Takai T; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan., Ogura T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan., Hirose M; Institute for Protein Research, Osaka University, Suita, Japan., Tokuda A; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan., Katamoto R; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan., Inoue A; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan., Asai E; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan., Kise R; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Sugita Y; Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan., Kato T; Institute for Protein Research, Osaka University, Suita, Japan., Nagase H; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan., Mitsutake A; Department of Physics, School of Science and Technology, Meiji University, Kawasaki, Kanagawa, Japan., Saitoh T; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan.; Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Katayama K; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.; OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan., Inoue A; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan., Kandori H; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.; OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan., Kobayashi T; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan. kobayatk@hirakata.kmu.ac.jp.; Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan. kobayatk@hirakata.kmu.ac.jp., Suno R; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan. suno.ryo@kmu.ac.jp.
Source: Nature communications [Nat Commun] 2025 Oct 28; Vol. 16 (1), pp. 9392. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Suno-Ikeda+C%22">Suno-Ikeda C</searchLink>; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan.<br /><searchLink fieldCode="AU" term="%22Nishikawa+R%22">Nishikawa R</searchLink>; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+R%22">Suzuki R</searchLink>; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yokoi+S%22">Yokoi S</searchLink>; Department of Physics, School of Science and Technology, Meiji University, Kawasaki, Kanagawa, Japan.; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Iwata+S%22">Iwata S</searchLink>; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Takai+T%22">Takai T</searchLink>; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan.<br /><searchLink fieldCode="AU" term="%22Ogura+T%22">Ogura T</searchLink>; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Hirose+M%22">Hirose M</searchLink>; Institute for Protein Research, Osaka University, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Tokuda+A%22">Tokuda A</searchLink>; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Katamoto+R%22">Katamoto R</searchLink>; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+A%22">Inoue A</searchLink>; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan.<br /><searchLink fieldCode="AU" term="%22Asai+E%22">Asai E</searchLink>; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan.<br /><searchLink fieldCode="AU" term="%22Kise+R%22">Kise R</searchLink>; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sugita+Y%22">Sugita Y</searchLink>; Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+T%22">Kato T</searchLink>; Institute for Protein Research, Osaka University, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Nagase+H%22">Nagase H</searchLink>; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Mitsutake+A%22">Mitsutake A</searchLink>; Department of Physics, School of Science and Technology, Meiji University, Kawasaki, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Saitoh+T%22">Saitoh T</searchLink>; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, Japan.; Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Katayama+K%22">Katayama K</searchLink>; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.; OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+A%22">Inoue A</searchLink>; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Kandori+H%22">Kandori H</searchLink>; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.; OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+T%22">Kobayashi T</searchLink>; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan. kobayatk@hirakata.kmu.ac.jp.; Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan. kobayatk@hirakata.kmu.ac.jp.<br /><searchLink fieldCode="AU" term="%22Suno+R%22">Suno R</searchLink>; Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan. suno.ryo@kmu.ac.jp.
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