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Clinical validation of a novel in vitro diagnostic neurofilament light chain assay for the prognostication of disease activity in people with relapsing multiple sclerosis.

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Title: Clinical validation of a novel in vitro diagnostic neurofilament light chain assay for the prognostication of disease activity in people with relapsing multiple sclerosis.
Authors: Ziemssen T; Center of Clinical Neuroscience, Department of Neurology, University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany., Freedman MS; Department of Medicine (Neurology), University of Ottawa; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Bar-Or A; Center for Neuroinflammation and Experimental Therapeutics, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Montalban X; Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain; Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Vic, Spain., Teunissen CE; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands., Häring DA; Novartis Pharma AG, Basel, Switzerland., Kukkaro P; Novartis Pharma AG, Basel, Switzerland., Merschhemke M; Novartis Pharma AG, Basel, Switzerland., Kieseier BC; Novartis Pharma AG, Basel, Switzerland., Karnik-Henry M; Siemens Healthineers, Tarrytown, NY, USA., Gee M; Siemens Healthineers, Tarrytown, NY, USA., Lange S; Siemens Healthineers, Tarrytown, NY, USA., Merabet E; Siemens Healthineers, Tarrytown, NY, USA., Chitnis T; Harvard Medical School; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital; Brigham Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Bittner S; Department of Neurology, Focus Program Translational Neuroscience and Immunology, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Wiendl H; Klinik für Neurologie und Neurophysiologie, Universitätsklinikum Freiburg, Freiburg, Germany., Hauser SL; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Source: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2025 Nov; Vol. 31 (13), pp. 1543-1556. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical validation of a novel in vitro diagnostic neurofilament light chain assay for the prognostication of disease activity in people with relapsing multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Ziemssen+T%22">Ziemssen T</searchLink>; Center of Clinical Neuroscience, Department of Neurology, University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Freedman+MS%22">Freedman MS</searchLink>; Department of Medicine (Neurology), University of Ottawa; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bar-Or+A%22">Bar-Or A</searchLink>; Center for Neuroinflammation and Experimental Therapeutics, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Montalban+X%22">Montalban X</searchLink>; Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain; Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Vic, Spain.<br /><searchLink fieldCode="AU" term="%22Teunissen+CE%22">Teunissen CE</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Häring+DA%22">Häring DA</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kukkaro+P%22">Kukkaro P</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Merschhemke+M%22">Merschhemke M</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kieseier+BC%22">Kieseier BC</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Karnik-Henry+M%22">Karnik-Henry M</searchLink>; Siemens Healthineers, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gee+M%22">Gee M</searchLink>; Siemens Healthineers, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lange+S%22">Lange S</searchLink>; Siemens Healthineers, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Merabet+E%22">Merabet E</searchLink>; Siemens Healthineers, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chitnis+T%22">Chitnis T</searchLink>; Harvard Medical School; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital; Brigham Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bittner+S%22">Bittner S</searchLink>; Department of Neurology, Focus Program Translational Neuroscience and Immunology, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Wiendl+H%22">Wiendl H</searchLink>; Klinik für Neurologie und Neurophysiologie, Universitätsklinikum Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hauser+SL%22">Hauser SL</searchLink>; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%229509185%22">Multiple sclerosis (Houndmills, Basingstoke, England)</searchLink> [Mult Scler] 2025 Nov; Vol. 31 (13), pp. 1543-1556. <i>Date of Electronic Publication: </i>2025 Oct 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9509185 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-0970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213524585%22">13524585 </searchLink><i>NLM ISO Abbreviation: </i>Mult Scler <i>Subsets: </i>MEDLINE
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              Text: 2025 Nov
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