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The INSPECTOR study: enhanced feasibility for clinical translation of a multi-cancer early detection method based on enzyme-assisted high signal-to-noise ratio sequencing of methylated circulating tumor DNA.

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Title: The INSPECTOR study: enhanced feasibility for clinical translation of a multi-cancer early detection method based on enzyme-assisted high signal-to-noise ratio sequencing of methylated circulating tumor DNA.
Authors: Luo HY; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China., Wei W; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China.; Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.; Department of Liver Surgery, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, P. R. China., Li P; Department of Early Cancer Screening Research and Development, GenePlus-Beijing Institute, Beijing, P. R. China., Zhang QH; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China.; Department of Research and Experimental, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Zhou Z; Department of Precision Medicine, GenePlus-Beijing Institute, Beijing, P. R. China., Cui L; Department of Precision Medicine, GenePlus-Beijing Institute, Beijing, P. R. China., Lin YB; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Yang H; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Zhong X; Department of Early Cancer Screening Research and Development, GenePlus-Beijing Institute, Beijing, P. R. China., Liu Q; Department of Early Cancer Screening Research and Development, GenePlus-Beijing Institute, Beijing, P. R. China., Yang H; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Luo KJ; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Qiu HB; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Yuan SQ; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Li YF; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Zhou ZW; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Lin XJ; Department of Hepatobiliary and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Cui BK; Department of Hepatobiliary and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Zhang RX; Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Fan WH; Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Huang H; Department of Gynaecology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Lan CY; Department of Gynaecology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Li JD; Department of Gynaecology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Wang ZQ; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Li BK; Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Guo RP; Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Tang J; Department of Breast Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Huang X; Department of Breast Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Xi M; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Liu Y; Physical Examination Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Xie C; Physical Examination Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China., Chen S; Department of Gastric Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, P. R. China., Li ZH; Department of Medical Oncology, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, P. R. China., Liu YH; Department of Medical Oncology, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, P. R. China., Zhang XT; Department of Science and Education, Shenzhen Bao'an District Songgang People's Hospital, Shenzhen, Guangdong, P. R. China., Zeng Q; Department of Laboratory, Chinese PLA General Hospital, Beijing, P. R. China., Yi X; Department of Precision Medicine, GenePlus-Beijing Institute, Beijing, P. R. China., Xu RH; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China.
Source: Cancer communications (London, England) [Cancer Commun (Lond)] 2025 Dec; Vol. 45 (12), pp. 1645-1665. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101723675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2523-3548 (Electronic) Linking ISSN: 25233548 NLM ISO Abbreviation: Cancer Commun (Lond) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The INSPECTOR study: enhanced feasibility for clinical translation of a multi-cancer early detection method based on enzyme-assisted high signal-to-noise ratio sequencing of methylated circulating tumor DNA.
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  Data: <searchLink fieldCode="AU" term="%22Luo+HY%22">Luo HY</searchLink>; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wei+W%22">Wei W</searchLink>; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China.; Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.; Department of Liver Surgery, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, P. R. China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Department of Early Cancer Screening Research and Development, GenePlus-Beijing Institute, Beijing, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+QH%22">Zhang QH</searchLink>; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China.; Department of Research and Experimental, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Department of Precision Medicine, GenePlus-Beijing Institute, Beijing, P. R. China.<br /><searchLink fieldCode="AU" term="%22Cui+L%22">Cui L</searchLink>; Department of Precision Medicine, GenePlus-Beijing Institute, Beijing, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lin+YB%22">Lin YB</searchLink>; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. 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China.<br /><searchLink fieldCode="AU" term="%22Cui+BK%22">Cui BK</searchLink>; Department of Hepatobiliary and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+RX%22">Zhang RX</searchLink>; Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Fan+WH%22">Fan WH</searchLink>; Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Gynaecology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lan+CY%22">Lan CY</searchLink>; Department of Gynaecology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Li+JD%22">Li JD</searchLink>; Department of Gynaecology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+ZQ%22">Wang ZQ</searchLink>; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Li+BK%22">Li BK</searchLink>; Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Guo+RP%22">Guo RP</searchLink>; Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China.<br /><searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; Department of Breast Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. 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