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Safety and efficacy of intratumourally administered INT230-6 in adult patients with advanced solid tumours: results from an open-label phase 1/2 dose escalation study.

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Title: Safety and efficacy of intratumourally administered INT230-6 in adult patients with advanced solid tumours: results from an open-label phase 1/2 dose escalation study.
Authors: Thomas JS; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Siu LL; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Ingham M; Columbia University Irving Medical Center, New York, NY, USA., Azad NS; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Meyer CF; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Olszanski AJ; Fox Chase Cancer Center, Philadelphia, PA, USA., Whalen GF; University of Massachusetts Memorial Medical Center, Worcester, MA, USA., Camacho LH; Center for Oncology and Blood Disorders, Houston, TX, USA., Hu JS; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hanna DL; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Cheng PM; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Abdul Razak AR; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Abbate F; Intensity Therapeutics, Inc., Shelton, CT, USA., Mahmood S; Intensity Therapeutics, Inc., Shelton, CT, USA., Walters IB; Intensity Therapeutics, Inc., Shelton, CT, USA., Bender LH; Intensity Therapeutics, Inc., Shelton, CT, USA., El-Khoueiry AB; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address: elkhouei@med.usc.edu.
Source: EBioMedicine [EBioMedicine] 2025 Nov; Vol. 121, pp. 105980. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and efficacy of intratumourally administered INT230-6 in adult patients with advanced solid tumours: results from an open-label phase 1/2 dose escalation study.
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  Data: <searchLink fieldCode="AU" term="%22Thomas+JS%22">Thomas JS</searchLink>; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Siu+LL%22">Siu LL</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ingham+M%22">Ingham M</searchLink>; Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Azad+NS%22">Azad NS</searchLink>; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+CF%22">Meyer CF</searchLink>; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Olszanski+AJ%22">Olszanski AJ</searchLink>; Fox Chase Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Whalen+GF%22">Whalen GF</searchLink>; University of Massachusetts Memorial Medical Center, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Camacho+LH%22">Camacho LH</searchLink>; Center for Oncology and Blood Disorders, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hu+JS%22">Hu JS</searchLink>; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hanna+DL%22">Hanna DL</searchLink>; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+PM%22">Cheng PM</searchLink>; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Abdul+Razak+AR%22">Abdul Razak AR</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Abbate+F%22">Abbate F</searchLink>; Intensity Therapeutics, Inc., Shelton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Mahmood+S%22">Mahmood S</searchLink>; Intensity Therapeutics, Inc., Shelton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Walters+IB%22">Walters IB</searchLink>; Intensity Therapeutics, Inc., Shelton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Bender+LH%22">Bender LH</searchLink>; Intensity Therapeutics, Inc., Shelton, CT, USA.<br /><searchLink fieldCode="AU" term="%22El-Khoueiry+AB%22">El-Khoueiry AB</searchLink>; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address: elkhouei@med.usc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2025 Nov; Vol. 121, pp. 105980. <i>Date of Electronic Publication: </i>2025 Oct 29.
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              Text: 2025 Nov
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