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Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.

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Title: Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.
Authors: Marques D; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Spindola L; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway., Narang A; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Vaziri N; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Stavrum A; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway., Jayaram M; Adult Mental Health Rehabilitation Unit, Mental Health and Wellbeing Services, Western Health, Sunshine Hospital, St Albans, VIC, Australia.; Department of Psychiatry, The University of Melbourne and Western Health, Western Centre for Health & Education, St Albans, VIC, Australia., Thomas N; Adult Mental Health Rehabilitation Unit, Mental Health and Wellbeing Services, Western Health, Sunshine Hospital, St Albans, VIC, Australia., Pantelis C; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.; Western Centre for Health Research & Education, University of Melbourne & Western Health, Sunshine Hospital, St Albans, Vic, Australia.; Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, Vic, Australia., Le Hellard S; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway., Hemberger M; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Dean W; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada., Greenway S; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Bousman C; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Psychiatry, The University of Melbourne and Western Health, Western Centre for Health & Education, St Albans, VIC, Australia.; Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Source: Journal of psychiatry & neuroscience : JPN [J Psychiatry Neurosci] 2025 Oct 01; Vol. 50 (5), pp. E323-E333. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 9107859 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1488-2434 (Electronic) Linking ISSN: 11804882 NLM ISO Abbreviation: J Psychiatry Neurosci Subsets: MEDLINE
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  Data: Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.
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  Data: <searchLink fieldCode="AU" term="%22Marques+D%22">Marques D</searchLink>; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Spindola+L%22">Spindola L</searchLink>; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Narang+A%22">Narang A</searchLink>; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Vaziri+N%22">Vaziri N</searchLink>; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Stavrum+A%22">Stavrum A</searchLink>; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Jayaram+M%22">Jayaram M</searchLink>; Adult Mental Health Rehabilitation Unit, Mental Health and Wellbeing Services, Western Health, Sunshine Hospital, St Albans, VIC, Australia.; Department of Psychiatry, The University of Melbourne and Western Health, Western Centre for Health & Education, St Albans, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Thomas+N%22">Thomas N</searchLink>; Adult Mental Health Rehabilitation Unit, Mental Health and Wellbeing Services, Western Health, Sunshine Hospital, St Albans, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pantelis+C%22">Pantelis C</searchLink>; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.; Western Centre for Health Research & Education, University of Melbourne & Western Health, Sunshine Hospital, St Albans, Vic, Australia.; Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, Vic, Australia.<br /><searchLink fieldCode="AU" term="%22Le+Hellard+S%22">Le Hellard S</searchLink>; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Hemberger+M%22">Hemberger M</searchLink>; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Dean+W%22">Dean W</searchLink>; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Greenway+S%22">Greenway S</searchLink>; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Bousman+C%22">Bousman C</searchLink>; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Psychiatry, The University of Melbourne and Western Health, Western Centre for Health & Education, St Albans, VIC, Australia.; Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
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        Value: 10.1139/jpn-25-0017
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      – TitleFull: Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.
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