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An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy.

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Title: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy.
Authors: Huffman JE; VA Boston Healthcare System, Boston, MA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Gaziano L; VA Boston Healthcare System, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Al Sayed ZR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Judy RL; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Raffield LM; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Biddinger KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA., Charest B; VA Boston Healthcare System, Boston, MA, USA., Chopra A; Bayer US, LLC, Cambridge, MA, USA., Gagnon D; VA Boston Healthcare System, Boston, MA, USA.; Boston University School of Public Health, Boston, MA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Koledova V; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Levin MG; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Min YI; University of Mississippi Medical Center, Jackson, MS, USA., Pirruccello JP; University of California San Francisco, San Francisco, CA, USA., Reza N; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Ruan R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Verma SS; University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Venkatesh BA; Johns Hopkins University, Baltimore, MD, USA., Verma A; University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Yao J; The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Carr JJ; Vanderbilt University Medical Center, Nashville, TN, USA., Casas JP; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Cho K; VA Boston Healthcare System, Boston, MA, USA., Lima JAC; Johns Hopkins University, Baltimore, MD, USA., Post WS; Johns Hopkins University, Baltimore, MD, USA., Rader DJ; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Ritchie MD; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Shah A; University of Texas Southwestern Medical Center, Dallas, TX, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Terry JG; Vanderbilt University Medical Center, Nashville, TN, USA., Rich SS; University of Virginia, Charlottesville, VA, USA., O'Donnell CJ; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Phillips LS; Emory University School of Medicine, Atlanta, GA, USA., Lunetta KL; Boston University School of Public Health, Boston, MA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Wilson PWF; Emory University School of Medicine, Atlanta, GA, USA.; Atlanta VA Medical Center, Decatur, GA, USA., Gaziano JM; VA Boston Healthcare System, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA., Damrauer SM; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Sun YV; Atlanta VA Medical Center, Decatur, GA, USA.; Emory University School of Public Health, Atlanta, GA, USA., Ellinor PT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA., Joseph J; VA Boston Healthcare System, Boston, MA, USA. jacob.joseph@va.gov.; Brown University, Providence, RI, USA. jacob.joseph@va.gov.; VA Providence Healthcare System, Providence, RI, USA. jacob.joseph@va.gov., Aragam KG; VA Boston Healthcare System, Boston, MA, USA. karagam@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.; Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org.; Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA. karagam@broadinstitute.org.
Corporate Authors: VA Million Veteran Program
Source: Nature genetics [Nat Genet] 2025 Nov; Vol. 57 (11), pp. 2682-2690. Date of Electronic Publication: 2025 Oct 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy.
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Brown University, Providence, RI, USA. jacob.joseph@va.gov.; VA Providence Healthcare System, Providence, RI, USA. jacob.joseph@va.gov.<br /><searchLink fieldCode="AU" term="%22Aragam+KG%22">Aragam KG</searchLink>; VA Boston Healthcare System, Boston, MA, USA. karagam@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.; Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org.; Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA. karagam@broadinstitute.org.
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