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Discovery of novel hybrid pyrrolidin-2-one derivatives exhibiting potent antiseizure and antinociceptive effects in preclinical models.

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Title: Discovery of novel hybrid pyrrolidin-2-one derivatives exhibiting potent antiseizure and antinociceptive effects in preclinical models.
Authors: Jakubiec M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Abram M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Zagaja M; Department of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland., Socała K; Department of Animal Physiology and Pharmacology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, Lublin 20-033, Poland., Panic V; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA., Latacz G; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Mogilski S; Department Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Szafarz M; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Szewczyk A; Department of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland., Saunders J; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA., West PJ; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA., Przejczowska-Pomierny K; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Stasiak K; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Słota J; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Jasiński J; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Czopek A; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Wyska E; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland., Wlaź P; Department of Animal Physiology and Pharmacology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, Lublin 20-033, Poland., Metcalf CS; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA., Wilcox K; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA., Andres-Mach M; Department of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland., Kamiński K; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland. Electronic address: k.kaminski@uj.edu.pl.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118728. Date of Electronic Publication: 2025 Nov 01.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Jakubiec+M%22">Jakubiec M</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Abram+M%22">Abram M</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Zagaja+M%22">Zagaja M</searchLink>; Department of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland.<br /><searchLink fieldCode="AU" term="%22Socała+K%22">Socała K</searchLink>; Department of Animal Physiology and Pharmacology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, Lublin 20-033, Poland.<br /><searchLink fieldCode="AU" term="%22Panic+V%22">Panic V</searchLink>; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Latacz+G%22">Latacz G</searchLink>; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Mogilski+S%22">Mogilski S</searchLink>; Department Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Szafarz+M%22">Szafarz M</searchLink>; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Szewczyk+A%22">Szewczyk A</searchLink>; Department of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland.<br /><searchLink fieldCode="AU" term="%22Saunders+J%22">Saunders J</searchLink>; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22West+PJ%22">West PJ</searchLink>; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Przejczowska-Pomierny+K%22">Przejczowska-Pomierny K</searchLink>; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Stasiak+K%22">Stasiak K</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Słota+J%22">Słota J</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Jasiński+J%22">Jasiński J</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Czopek+A%22">Czopek A</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Wyska+E%22">Wyska E</searchLink>; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.<br /><searchLink fieldCode="AU" term="%22Wlaź+P%22">Wlaź P</searchLink>; Department of Animal Physiology and Pharmacology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, Lublin 20-033, Poland.<br /><searchLink fieldCode="AU" term="%22Metcalf+CS%22">Metcalf CS</searchLink>; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Wilcox+K%22">Wilcox K</searchLink>; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Andres-Mach+M%22">Andres-Mach M</searchLink>; Department of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland.<br /><searchLink fieldCode="AU" term="%22Kamiński+K%22">Kamiński K</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland. Electronic address: k.kaminski@uj.edu.pl.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118728. <i>Date of Electronic Publication: </i>2025 Nov 01.
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