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Discovery of 2-aryl-1H-pyrazole-S-DACO analogs as novel inhibitors targeting the DENV NS5 protein.

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Title: Discovery of 2-aryl-1H-pyrazole-S-DACO analogs as novel inhibitors targeting the DENV NS5 protein.
Authors: Liu JY; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Xue JX; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China., Pan WK; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Zhou GF; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China., Xie CQ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Yan KT; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Wu JR; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Niu DY; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Luo RH; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China., Wang YP; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Ding YL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China., Zheng YT; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China., Zhang HB; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China. Electronic address: zhanghb@ynu.edu.cn., Yang LM; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. Electronic address: lmyang@mail.kiz.ac.cn., He YP; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China. Electronic address: yphe@ynu.edu.cn.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109158. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of 2-aryl-1H-pyrazole-S-DACO analogs as novel inhibitors targeting the DENV NS5 protein.
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  Data: <searchLink fieldCode="AU" term="%22Liu+JY%22">Liu JY</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Xue+JX%22">Xue JX</searchLink>; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Pan+WK%22">Pan WK</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Zhou+GF%22">Zhou GF</searchLink>; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Xie+CQ%22">Xie CQ</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Yan+KT%22">Yan KT</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Wu+JR%22">Wu JR</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Niu+DY%22">Niu DY</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Luo+RH%22">Luo RH</searchLink>; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Wang+YP%22">Wang YP</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Ding+YL%22">Ding YL</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Zheng+YT%22">Zheng YT</searchLink>; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+HB%22">Zhang HB</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China. Electronic address: zhanghb@ynu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+LM%22">Yang LM</searchLink>; State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. Electronic address: lmyang@mail.kiz.ac.cn.<br /><searchLink fieldCode="AU" term="%22He+YP%22">He YP</searchLink>; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, China. Electronic address: yphe@ynu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109158. <i>Date of Electronic Publication: </i>2025 Oct 27.
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        Value: 10.1016/j.bioorg.2025.109158
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      – Code: eng
        Text: English
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        StartPage: 109158
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      – TitleFull: Discovery of 2-aryl-1H-pyrazole-S-DACO analogs as novel inhibitors targeting the DENV NS5 protein.
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            – D: 01
              M: 11
              Text: 2025 Nov
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