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Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function.

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Title: Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function.
Authors: Jenkins BJ; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Jenkins YR; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Ponce-Garcia FM; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Moscrop C; Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, UK., Perry IA; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Hitchings MD; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Uribe AH; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Bernuzzi F; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Eastham S; Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, UK., Cronin JG; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Berisha A; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co, Kildare, Ireland., Howell A; Diabetes Research Group, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Davies J; Diabetes Research Group, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Blagih J; The Francis Crick Institute, 1 Midland Road, London, UK.; University of Montreal, Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada., Williams M; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK., Marsden M; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK., Veale DJ; EULAR Centre of Excellence, Centre for Arthritis and Rheumatic Diseases, St Vincent's University Hospital, Dublin, Ireland., Davies LC; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Niphakis M; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Finlay DK; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Sinclair LV; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Hogan AE; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co, Kildare, Ireland., Nathan JA; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, UK., Humphreys IR; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK., Fearon U; Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Sumpton D; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Vande Voorde J; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK., Vale GDD; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA., McDonald JG; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Jones GW; Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, UK., Pearson JA; Diabetes Research Group, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Vincent EE; School of Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.; Integrative Epidemiology Unit, School of Population Health Science, University of Bristol, Bristol, UK., Jones N; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK. n.jones@swansea.ac.uk.
Source: Nature communications [Nat Commun] 2025 Nov 03; Vol. 16 (1), pp. 9484. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Jenkins+BJ%22">Jenkins BJ</searchLink>; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK.<br /><searchLink fieldCode="AU" term="%22Jenkins+YR%22">Jenkins YR</searchLink>; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK.<br /><searchLink fieldCode="AU" term="%22Ponce-Garcia+FM%22">Ponce-Garcia FM</searchLink>; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK.<br /><searchLink fieldCode="AU" term="%22Moscrop+C%22">Moscrop C</searchLink>; Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Perry+IA%22">Perry IA</searchLink>; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK.<br /><searchLink fieldCode="AU" term="%22Hitchings+MD%22">Hitchings MD</searchLink>; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK.<br /><searchLink fieldCode="AU" term="%22Uribe+AH%22">Uribe AH</searchLink>; 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Diabetes Research Group, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Blagih+J%22">Blagih J</searchLink>; The Francis Crick Institute, 1 Midland Road, London, UK.; University of Montreal, Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Williams+M%22">Williams M</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Marsden+M%22">Marsden M</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Veale+DJ%22">Veale DJ</searchLink>; EULAR Centre of Excellence, Centre for Arthritis and Rheumatic Diseases, St Vincent's University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Davies+LC%22">Davies LC</searchLink>; 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Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Humphreys+IR%22">Humphreys IR</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Fearon+U%22">Fearon U</searchLink>; Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Sumpton+D%22">Sumpton D</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Vande+Voorde+J%22">Vande Voorde J</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Vale+GDD%22">Vale GDD</searchLink>; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+JG%22">McDonald JG</searchLink>; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jones+GW%22">Jones GW</searchLink>; Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Pearson+JA%22">Pearson JA</searchLink>; Diabetes Research Group, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Vincent+EE%22">Vincent EE</searchLink>; School of Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.; Integrative Epidemiology Unit, School of Population Health Science, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Jones+N%22">Jones N</searchLink>; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK. n.jones@swansea.ac.uk.
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