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Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR.

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Title: Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR.
Authors: White N; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Chalk JA; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; Cell and Gene therapy Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK., Hu YT; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Pins SM; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Joseph CR; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden., Antoniou P; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden., Wimberger S; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden., Svensson S; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Caetano-Silva SP; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Mudde ACA; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Rai R; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Selvaraj S; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA., Feist WN; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA., Romito M; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Sienski G; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden., Nitsch R; Cell and Gene therapy Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Gothenburg, Sweden., Booth C; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Santilli G; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Cavazza A; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Porteus MH; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA., Maresca M; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden., Thrasher AJ; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Turchiano G; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom. g.turchiano@ucl.ac.uk.; Cell and Gene therapy Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK. g.turchiano@ucl.ac.uk.
Source: Nature communications [Nat Commun] 2025 Nov 03; Vol. 16 (1), pp. 9571. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR.
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Department of Pediatrics, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Maresca+M%22">Maresca M</searchLink>; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Thrasher+AJ%22">Thrasher AJ</searchLink>; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Turchiano+G%22">Turchiano G</searchLink>; Infection, Immunity, and Inflammation Teaching and Research Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom. g.turchiano@ucl.ac.uk.; Cell and Gene therapy Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK. g.turchiano@ucl.ac.uk.
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