Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery.
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| Title: | Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery. |
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| Authors: | Hirschberger S; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Müller MB; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Mascolo H; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Seitz M; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Nibler S; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Effinger D; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Lu K; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Büch J; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany., Bender M; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Kammerer T; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany., Peterß S; Department of Cardiac Surgery, LMU University Hospital, LMU, Munich, Germany., Kleigrewe K; Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Abele M; Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Barth T; Protein Analysis Unit, BioMedical Center, Faculty of Medicine, LMU, Martinsried, Germany., Kushnir O; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Imhof A; Protein Analysis Unit, BioMedical Center, Faculty of Medicine, LMU, Martinsried, Germany., Dietzel S; Core Facility Bioimaging and Walter Brendel Center of Experimental Medicine, Biomedical Center, LMU, Munich, Germany.; Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine, LMU, Munich, Germany., Wegener B; Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, LMU University Hospital, LMU, Munich, Germany., Sowa R; Department of Anesthesiology and Intensive Care Medicine, University Medical Center Goettingen, Goettingen, Germany., Vogel F; Artemed Hospital Munich South, Munich, Germany., Lamm P; Artemed Hospital Munich South, Munich, Germany., Tomasi R; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Unger K; Department of Radiotherapy and Radiooncology, LMU University Hospital, LMU, Munich, Germany., Sperandio M; Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine, LMU, Munich, Germany., Kilger E; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany., Kreth S; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany. simone.kreth@med.uni-muenchen.de.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany. simone.kreth@med.uni-muenchen.de., Hübner M; Walter Brendel Center of Experimental Medicine, Research Unit Immune Function and Immune Metabolism, Ludwig-Maximilian-University (LMU), Munich, Germany.; Department of Anaesthesiology, LMU University Hospital, LMU, Munich, Germany. |
| Source: | EMBO molecular medicine [EMBO Mol Med] 2025 Dec; Vol. 17 (12), pp. 3329-3354. Date of Electronic Publication: 2025 Nov 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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