Toxicity-related immunotherapy discontinuation and outcome in patients with advanced renal cell carcinoma treated with immune-based combinations (ARON-1 study).

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Title: Toxicity-related immunotherapy discontinuation and outcome in patients with advanced renal cell carcinoma treated with immune-based combinations (ARON-1 study).
Authors: Molina-Cerrillo J; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain., Roviello G; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy., Bourlon MT; Department of Hemato-Oncology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.; Universidad Panamericana, Escuela de Medicina, Mexico City, Mexico., Studentova H; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic., Fiala O; Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic.; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic., Cerbone L; Department of Medical Oncology, San Camillo Forlanini Hospital, Rome, Italy., Kucharz J; Department of Uro-Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Ansari J; Medical Oncology, Tawam Hospital, Al Ain, UAE., Zeppellini A; Medical Oncology, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Taha T; Royal Marsden NHS Foundation Trust, London, UK., Buti S; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.; Department of Medicine and Surgery, University of Parma, Parma, Italy., Ürün Y; Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Türkiye., Scagliarini S; Department of Medical Oncology, AORN 'A. Cardarelli', Naples, Italy., Li H; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Cancer Center, Westwood, Ksansas, USA., Sunela K; Department of Oncology, Tampere University Hospital, Tampere Cancer Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Park SH; Department of Hematology and Oncology, Sungkyunkwan University Samsung Medical Center, Seoul, South Korea., Rizzo M; Medical Oncology Unit, Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari, Bari, Italy., Zgura A; Department of Oncology-Radiotherapy, Prof. Dr. Alexandru Trestioreanu Institute of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Chiari R; Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Pesaro y Urbino, Italy., Seront E; Department of Medical Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium., Catalano M; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy., Ghosn M; Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon., Filosa A; Anatomic Pathology, Department of Biomedical Sciences and Public Health, University 'Politecnica delle Marche', Ancona, Italy., Soares A; Latin American Cooperative Oncology Group - LACOG, Porto Alegre, Brazil.; Oncology Unit, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Massari F; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Monteiro FSM; Latin American Cooperative Oncology Group - LACOG, Porto Alegre, Brazil.; Oncology and Hematology Department, Hospital Sírio Libanês, Brasília, Brazil., Grande E; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain., Porta C; Chair of Oncology, Interdisciplinary Department of Medicine, University of Bari 'Aldo Moro', Bari, Italy., Bracarda S; Medical Oncology, Azienda Ospedaliera Santa Maria, Terni, Italy., Santoni M; Medical Oncology Unit, Macerata Hospital, Macerata, Italy.
Source: International journal of cancer [Int J Cancer] 2026 Mar 01; Vol. 158 (5), pp. 1396-1405. Date of Electronic Publication: 2025 Nov 04.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
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  Data: Toxicity-related immunotherapy discontinuation and outcome in patients with advanced renal cell carcinoma treated with immune-based combinations (ARON-1 study).
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  Data: <searchLink fieldCode="AU" term="%22Molina-Cerrillo+J%22">Molina-Cerrillo J</searchLink>; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Roviello+G%22">Roviello G</searchLink>; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bourlon+MT%22">Bourlon MT</searchLink>; Department of Hemato-Oncology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.; Universidad Panamericana, Escuela de Medicina, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Studentova+H%22">Studentova H</searchLink>; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Fiala+O%22">Fiala O</searchLink>; Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic.; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Cerbone+L%22">Cerbone L</searchLink>; Department of Medical Oncology, San Camillo Forlanini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Kucharz+J%22">Kucharz J</searchLink>; Department of Uro-Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Ansari+J%22">Ansari J</searchLink>; Medical Oncology, Tawam Hospital, Al Ain, UAE.<br /><searchLink fieldCode="AU" term="%22Zeppellini+A%22">Zeppellini A</searchLink>; Medical Oncology, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Taha+T%22">Taha T</searchLink>; Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Buti+S%22">Buti S</searchLink>; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.; Department of Medicine and Surgery, University of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Ürün+Y%22">Ürün Y</searchLink>; Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Türkiye.<br /><searchLink fieldCode="AU" term="%22Scagliarini+S%22">Scagliarini S</searchLink>; Department of Medical Oncology, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Cancer Center, Westwood, Ksansas, USA.<br /><searchLink fieldCode="AU" term="%22Sunela+K%22">Sunela K</searchLink>; Department of Oncology, Tampere University Hospital, Tampere Cancer Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; Department of Hematology and Oncology, Sungkyunkwan University Samsung Medical Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Rizzo+M%22">Rizzo M</searchLink>; Medical Oncology Unit, Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Zgura+A%22">Zgura A</searchLink>; Department of Oncology-Radiotherapy, Prof. Dr. Alexandru Trestioreanu Institute of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Chiari+R%22">Chiari R</searchLink>; Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Pesaro y Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Seront+E%22">Seront E</searchLink>; Department of Medical Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Catalano+M%22">Catalano M</searchLink>; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Ghosn+M%22">Ghosn M</searchLink>; Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon.<br /><searchLink fieldCode="AU" term="%22Filosa+A%22">Filosa A</searchLink>; Anatomic Pathology, Department of Biomedical Sciences and Public Health, University 'Politecnica delle Marche', Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Soares+A%22">Soares A</searchLink>; Latin American Cooperative Oncology Group - LACOG, Porto Alegre, Brazil.; Oncology Unit, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Massari+F%22">Massari F</searchLink>; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Monteiro+FSM%22">Monteiro FSM</searchLink>; Latin American Cooperative Oncology Group - LACOG, Porto Alegre, Brazil.; Oncology and Hematology Department, Hospital Sírio Libanês, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22Grande+E%22">Grande E</searchLink>; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Porta+C%22">Porta C</searchLink>; Chair of Oncology, Interdisciplinary Department of Medicine, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Bracarda+S%22">Bracarda S</searchLink>; Medical Oncology, Azienda Ospedaliera Santa Maria, Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Santoni+M%22">Santoni M</searchLink>; Medical Oncology Unit, Macerata Hospital, Macerata, Italy.
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  Data: <searchLink fieldCode="JN" term="%220042124%22">International journal of cancer</searchLink> [Int J Cancer] 2026 Mar 01; Vol. 158 (5), pp. 1396-1405. <i>Date of Electronic Publication: </i>2025 Nov 04.
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