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Generation of exogenous kidneys via CRISPR/Cas9 mediated blastocyst complementation targeting Osr1 gene in mice.

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Title: Generation of exogenous kidneys via CRISPR/Cas9 mediated blastocyst complementation targeting Osr1 gene in mice.
Authors: Yeh TY; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 402, Taiwan., Chiu IM; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 402, Taiwan.; Neuroscience and Brain Disease Center, China Medical University, Taichung, 404, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan.; Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA., Huang YJ; Department of Animal Science and Technology, National Taiwan University, Taipei, 106, Taiwan., Wu SC; Department of Animal Science and Technology, National Taiwan University, Taipei, 106, Taiwan., Hsieh CC; National Laboratory Animal Center, National Applied Research Laboratories, Taipei, 115, Taiwan., Sung HH; National Laboratory Animal Center, National Applied Research Laboratories, Taipei, 115, Taiwan., Hwu WL; Center for Precision Medicine, China Medical University Hospital, Taichung, 404, Taiwan., Wang GJ; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 402, Taiwan. gjwang@dragon.nchu.edu.tw.; Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, 402, Taiwan. gjwang@dragon.nchu.edu.tw.; Department of Mechanical Engineering, National Chung Hsing University, Taichung, 402, Taiwan. gjwang@dragon.nchu.edu.tw., Ju JC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan. jcju@dragon.nchu.edu.tw.; Center for Precision Medicine, China Medical University Hospital, Taichung, 404, Taiwan. jcju@dragon.nchu.edu.tw.; Department of Animal Science, National Chung Hsing University, Taichung, 402, Taiwan. jcju@dragon.nchu.edu.tw.
Source: Scientific reports [Sci Rep] 2025 Nov 04; Vol. 15 (1), pp. 38648. Date of Electronic Publication: 2025 Nov 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Generation of exogenous kidneys via CRISPR/Cas9 mediated blastocyst complementation targeting Osr1 gene in mice.
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  Data: <searchLink fieldCode="AU" term="%22Yeh+TY%22">Yeh TY</searchLink>; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 402, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+IM%22">Chiu IM</searchLink>; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 402, Taiwan.; Neuroscience and Brain Disease Center, China Medical University, Taichung, 404, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan.; Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Huang+YJ%22">Huang YJ</searchLink>; Department of Animal Science and Technology, National Taiwan University, Taipei, 106, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+SC%22">Wu SC</searchLink>; Department of Animal Science and Technology, National Taiwan University, Taipei, 106, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+CC%22">Hsieh CC</searchLink>; National Laboratory Animal Center, National Applied Research Laboratories, Taipei, 115, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sung+HH%22">Sung HH</searchLink>; National Laboratory Animal Center, National Applied Research Laboratories, Taipei, 115, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hwu+WL%22">Hwu WL</searchLink>; Center for Precision Medicine, China Medical University Hospital, Taichung, 404, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+GJ%22">Wang GJ</searchLink>; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 402, Taiwan. gjwang@dragon.nchu.edu.tw.; Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, 402, Taiwan. gjwang@dragon.nchu.edu.tw.; Department of Mechanical Engineering, National Chung Hsing University, Taichung, 402, Taiwan. gjwang@dragon.nchu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Ju+JC%22">Ju JC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan. jcju@dragon.nchu.edu.tw.; Center for Precision Medicine, China Medical University Hospital, Taichung, 404, Taiwan. jcju@dragon.nchu.edu.tw.; Department of Animal Science, National Chung Hsing University, Taichung, 402, Taiwan. jcju@dragon.nchu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2025 Nov 04; Vol. 15 (1), pp. 38648. <i>Date of Electronic Publication: </i>2025 Nov 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41598-025-22373-9
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              Text: 2025 Nov 04
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