Generation of antigen-specific paired-chain antibodies using large language models.

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Bibliographic Details
Title: Generation of antigen-specific paired-chain antibodies using large language models.
Authors: Wasdin PT; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Janke AK; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Held S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Marinov TM; Center for Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Jordaan G; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Gillespie RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Vandenabeele L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Pantouli F; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL 34987, USA., Powers OC; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Vukovich MJ; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Holt CM; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Kim J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Hansman G; Institute for Biomedicine and Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia., Logue J; Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA, USA., Chu HY; Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA, USA., Andrews SF; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kanekiyo M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Sautto GA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL 34987, USA., Ross TM; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL 34987, USA., Sheward DJ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Abu-Shmais AA; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Georgiev IS; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Computer Science, Vanderbilt University, Nashville, TN, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37237, USA. Electronic address: ivelin.georgiev@vumc.org.
Source: Cell [Cell] 2025 Dec 11; Vol. 188 (25), pp. 7206-7221.e16. Date of Electronic Publication: 2025 Nov 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2025.10.006