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The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects.

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Title: The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects.
Authors: Luethi D; Psychopharmacology Research, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. dino.luethi@unibas.ch., Glatfelter GC; Designer Drug Research Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, US., Pottie E; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Sellitti F; Neuropharmacology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Maitland AD; Designer Drug Research Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, US., Gonzalez NR; Designer Drug Research Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, US., Kryszak LA; Translational Analytical Core, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, US., Jackson SN; Translational Analytical Core, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, US., Hoener MC; Neuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Stove CP; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Liechti ME; Psychopharmacology Research, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Smieško M; Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Société des Produits Nestlé, Nestlé Research, Lausanne, Switzerland., Baumann MH; Designer Drug Research Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, US., Simmler LD; Neuropharmacology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Rudin D; Psychopharmacology Research, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Mar; Vol. 31 (3), pp. 1799-1809. Date of Electronic Publication: 2025 Nov 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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