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Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer.

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Title: Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer.
Authors: Jameson GS; HonorHealth Research Institute, Scottsdale, AZ, USA. Electronic address: gjameson@HonorHealth.com., LeGrand SD; HonorHealth Research Institute, Scottsdale, AZ, USA., Gordon MS; HonorHealth Research Institute, Scottsdale, AZ, USA; Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, AZ, USA., Roe DJ; The University of Arizona Cancer Center, Tucson, AZ, USA., Wertheim BC; The University of Arizona Cancer Center, Tucson, AZ, USA., Olszewski K; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA., Rabinowitz J; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA., Evans R; Salk Institute, La Jolla, CA, USA., Downes M; Salk Institute, La Jolla, CA, USA., Truitt M; Salk Institute, La Jolla, CA, USA., Korn R; Imaging Endpoints, Scottsdale, AZ, USA., Han H; Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, AZ, USA., Miller RM; HonorHealth Research Institute, Scottsdale, AZ, USA., Barrett MT; Mayo Clinic, Scottsdale, AZ, USA., Propper D; Barts Cancer Institute, Queen Mary University of London, London, UK., Von Hoff DD; HonorHealth Research Institute, Scottsdale, AZ, USA; Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, AZ, USA., Borazanci E; HonorHealth Research Institute, Scottsdale, AZ, USA.
Source: Redox biology [Redox Biol] 2025 Dec; Vol. 88, pp. 103895. Date of Electronic Publication: 2025 Oct 25.
Publication Type: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Jameson+GS%22">Jameson GS</searchLink>; HonorHealth Research Institute, Scottsdale, AZ, USA. Electronic address: gjameson@HonorHealth.com.<br /><searchLink fieldCode="AU" term="%22LeGrand+SD%22">LeGrand SD</searchLink>; HonorHealth Research Institute, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Gordon+MS%22">Gordon MS</searchLink>; HonorHealth Research Institute, Scottsdale, AZ, USA; Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Roe+DJ%22">Roe DJ</searchLink>; The University of Arizona Cancer Center, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Wertheim+BC%22">Wertheim BC</searchLink>; The University of Arizona Cancer Center, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Olszewski+K%22">Olszewski K</searchLink>; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Rabinowitz+J%22">Rabinowitz J</searchLink>; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Evans+R%22">Evans R</searchLink>; Salk Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Downes+M%22">Downes M</searchLink>; Salk Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Truitt+M%22">Truitt M</searchLink>; Salk Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Korn+R%22">Korn R</searchLink>; Imaging Endpoints, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Han+H%22">Han H</searchLink>; Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Miller+RM%22">Miller RM</searchLink>; HonorHealth Research Institute, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Barrett+MT%22">Barrett MT</searchLink>; Mayo Clinic, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Propper+D%22">Propper D</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Von+Hoff+DD%22">Von Hoff DD</searchLink>; HonorHealth Research Institute, Scottsdale, AZ, USA; Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Borazanci+E%22">Borazanci E</searchLink>; HonorHealth Research Institute, Scottsdale, AZ, USA.
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  Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2025 Dec; Vol. 88, pp. 103895. <i>Date of Electronic Publication: </i>2025 Oct 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE
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              Text: 2025 Dec
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