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Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health records.

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Title: Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health records.
Authors: Sampri A; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK. Electronic address: as3293@medschl.cam.ac.uk., Shi W; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Bolton T; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK., Ip S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Cambridge Centre for AI in Medicine, UK., Knight R; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit, Bristol, UK., Walker V; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit, Bristol, UK; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Denholm R; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; NIHR Bristol Biomedical Research Centre, Bristol, UK; Health Data Research UK South-West, Bristol, UK., Raffetti E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden., Keene S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK., Allara E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK., Jiang X; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Kontopantelis E; Division of Informatics, Imaging, and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Denaxas S; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; Institute of Health Informatics, University College London, London, UK; Health Data Research UK, London, UK; University College London Hospitals Biomedical Research Centre, University College London, London, UK; BHF Accelerator, London, UK; Interdisciplinary Transformation University, Linz, Austria., Khunti K; Diabetes Research Centre, University of Leicester, Leicester, UK., Conrad N; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Pagel C; Clinical Operational Research Unit, University College London, London, UK., Hardelid P; Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK; UCL Great Ormond Street Institute of Child Health, London, UK., Sterne JAC; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; NIHR Bristol Biomedical Research Centre, Bristol, UK; Health Data Research UK South-West, Bristol, UK., Brown KL; Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK; Institute of Cardiovascular Science, University College London, London, UK., Whiteley WN; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; Health Data Research UK, London, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Usher Institute, University of Edinburgh, Edinburgh, UK., Cezard G; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Wood AM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK; NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Corporate Authors: CVD-COVID-UK/COVID-IMPACT Consortium and the Longitudinal Health Wellbeing COVID-19 National Core Study
Source: The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2025 Dec; Vol. 9 (12), pp. 837-847.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101712925 Publication Model: Print Cited Medium: Internet ISSN: 2352-4650 (Electronic) Linking ISSN: 23524642 NLM ISO Abbreviation: Lancet Child Adolesc Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health records.
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  Data: <searchLink fieldCode="AU" term="%22Sampri+A%22">Sampri A</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK. Electronic address: as3293@medschl.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Shi+W%22">Shi W</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bolton+T%22">Bolton T</searchLink>; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK.<br /><searchLink fieldCode="AU" term="%22Ip+S%22">Ip S</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Cambridge Centre for AI in Medicine, UK.<br /><searchLink fieldCode="AU" term="%22Knight+R%22">Knight R</searchLink>; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Walker+V%22">Walker V</searchLink>; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit, Bristol, UK; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Denholm+R%22">Denholm R</searchLink>; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; NIHR Bristol Biomedical Research Centre, Bristol, UK; Health Data Research UK South-West, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Raffetti+E%22">Raffetti E</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Keene+S%22">Keene S</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Allara+E%22">Allara E</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kontopantelis+E%22">Kontopantelis E</searchLink>; Division of Informatics, Imaging, and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Denaxas+S%22">Denaxas S</searchLink>; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; Institute of Health Informatics, University College London, London, UK; Health Data Research UK, London, UK; University College London Hospitals Biomedical Research Centre, University College London, London, UK; BHF Accelerator, London, UK; Interdisciplinary Transformation University, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Khunti+K%22">Khunti K</searchLink>; Diabetes Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Conrad+N%22">Conrad N</searchLink>; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pagel+C%22">Pagel C</searchLink>; Clinical Operational Research Unit, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hardelid+P%22">Hardelid P</searchLink>; Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK; UCL Great Ormond Street Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Sterne+JAC%22">Sterne JAC</searchLink>; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; NIHR Bristol Biomedical Research Centre, Bristol, UK; Health Data Research UK South-West, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Brown+KL%22">Brown KL</searchLink>; Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK; Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Whiteley+WN%22">Whiteley WN</searchLink>; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; Health Data Research UK, London, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Usher Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Cezard+G%22">Cezard G</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wood+AM%22">Wood AM</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK; NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
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