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Novel insights into cyanobacterial (microcystins) neurotoxicity in rats: hepatic encephalopathy.

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Title: Novel insights into cyanobacterial (microcystins) neurotoxicity in rats: hepatic encephalopathy.
Authors: Xu WL; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Chen L; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.; Southwest United Graduate School, Kunming, 650092, China., Fan HH; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. fhh@wmu.edu.cn.; College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China. fhh@wmu.edu.cn.; Department of Preventive Medicine, Institute of Nutrition and Diseases, Wenzhou Medical University, Wenzhou, 325035, China. fhh@wmu.edu.cn., Codd GA; School of Natural Sciences, University of Stirling, Stirling, FK9 4LA, UK.; School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Giesy JP; Department of Integrative Biology, Michigan State University, East Lansing, MI, 48895, USA.; Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, SK, S7N 5B3, Canada.; Department of Environmental Sciences, Baylor University, Waco, TX, 76798-7266, USA., Guo YM; Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Australia.; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Australia., Hilborn ED; United States Environmental Protection Agency (USEPA), Office of Research and Development, Center for Public Health and Environmental Assessment, Research Triangle Park, NC, 27514, USA., Sedan D; Environmental Center Research, National Council of Science and Technology, National University of La Plata. Centro de Investigaciones del Medio Ambiente (CIM)/CONICET-UNLP, La Plata 1900, Buenos Aires, Argentina., Andrinolo D; Environmental Center Research, National Council of Science and Technology, National University of La Plata. Centro de Investigaciones del Medio Ambiente (CIM)/CONICET-UNLP, La Plata 1900, Buenos Aires, Argentina., Chatterjee S; Department of Environmental and Occupational Health, University of California Irvine, Irvine, 92697, USA.; Division of Infectious Disease, Department of Medicine, University of California Irvine, Irvine, 92697, USA., Wang HJ; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.; Southwest United Graduate School, Kunming, 650092, China., Liu Y; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China., Wu QH; School of Ecology and Environment, Anhui Normal University, Wuhu, 241002, China., He J; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Dai SM; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Xu LL; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Xiao SM; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China., Liu YQ; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China., Yang R; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China., Chen J; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. chenjun@ihb.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. chenjun@ihb.ac.cn., Xie P; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. wildbull@ihb.ac.cn.; College of Life Sciences, Hebei University, Baoding, 071002, China. wildbull@ihb.ac.cn.
Source: Archives of toxicology [Arch Toxicol] 2026 Feb; Vol. 100 (2), pp. 737-754. Date of Electronic Publication: 2025 Nov 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel insights into cyanobacterial (microcystins) neurotoxicity in rats: hepatic encephalopathy.
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  Data: <searchLink fieldCode="AU" term="%22Xu+WL%22">Xu WL</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.; Southwest United Graduate School, Kunming, 650092, China.<br /><searchLink fieldCode="AU" term="%22Fan+HH%22">Fan HH</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. fhh@wmu.edu.cn.; College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China. fhh@wmu.edu.cn.; Department of Preventive Medicine, Institute of Nutrition and Diseases, Wenzhou Medical University, Wenzhou, 325035, China. fhh@wmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Codd+GA%22">Codd GA</searchLink>; School of Natural Sciences, University of Stirling, Stirling, FK9 4LA, UK.; School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Giesy+JP%22">Giesy JP</searchLink>; Department of Integrative Biology, Michigan State University, East Lansing, MI, 48895, USA.; Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, SK, S7N 5B3, Canada.; Department of Environmental Sciences, Baylor University, Waco, TX, 76798-7266, USA.<br /><searchLink fieldCode="AU" term="%22Guo+YM%22">Guo YM</searchLink>; Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Australia.; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Hilborn+ED%22">Hilborn ED</searchLink>; United States Environmental Protection Agency (USEPA), Office of Research and Development, Center for Public Health and Environmental Assessment, Research Triangle Park, NC, 27514, USA.<br /><searchLink fieldCode="AU" term="%22Sedan+D%22">Sedan D</searchLink>; Environmental Center Research, National Council of Science and Technology, National University of La Plata. Centro de Investigaciones del Medio Ambiente (CIM)/CONICET-UNLP, La Plata 1900, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Andrinolo+D%22">Andrinolo D</searchLink>; Environmental Center Research, National Council of Science and Technology, National University of La Plata. Centro de Investigaciones del Medio Ambiente (CIM)/CONICET-UNLP, La Plata 1900, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Chatterjee+S%22">Chatterjee S</searchLink>; Department of Environmental and Occupational Health, University of California Irvine, Irvine, 92697, USA.; Division of Infectious Disease, Department of Medicine, University of California Irvine, Irvine, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Wang+HJ%22">Wang HJ</searchLink>; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.; Southwest United Graduate School, Kunming, 650092, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.<br /><searchLink fieldCode="AU" term="%22Wu+QH%22">Wu QH</searchLink>; School of Ecology and Environment, Anhui Normal University, Wuhu, 241002, China.<br /><searchLink fieldCode="AU" term="%22He+J%22">He J</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Dai+SM%22">Dai SM</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Xu+LL%22">Xu LL</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Xiao+SM%22">Xiao SM</searchLink>; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.<br /><searchLink fieldCode="AU" term="%22Liu+YQ%22">Liu YQ</searchLink>; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Qilu Lake Field Observation and Research Station for Plateau Shallow Lake in Yunnan Province, Yunnan Key Laboratory of Ecological Protection and Resource Utilization of River-Lake Networks, Institute for Ecological Research and Pollution Control of Plateau Lakes, State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.; Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. chenjun@ihb.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. chenjun@ihb.ac.cn.<br /><searchLink fieldCode="AU" term="%22Xie+P%22">Xie P</searchLink>; Donghu Experimental Station of Lake Ecosystems, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. wildbull@ihb.ac.cn.; College of Life Sciences, Hebei University, Baoding, 071002, China. wildbull@ihb.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Feb; Vol. 100 (2), pp. 737-754. <i>Date of Electronic Publication: </i>2025 Nov 07.
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              Text: 2026 Feb
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