Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity.

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Title: Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity.
Authors: Jamieson PJ; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Shen X; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA., Abu-Shmais AA; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wasdin PT; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Janowska K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA., Edwards RJ; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA., Scapellato G; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA., Bukenya M; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.; Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA., Bass LE; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Richardson SI; South African Medical Research Council Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Manamela NP; South African Medical Research Council Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Liu S; Worcester HIV Vaccine, Worcester, Massachusetts, USA., Barr M; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA., Adams L; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA., Paola Velez-Castro C; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA., McCarthy C; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA., Alexander CA; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA., Gillespie RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, Bethesda, Maryland, USA., Mimms J; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Suryadevara N; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sornberger TA; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Zost SJ; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Parks R; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA., Flaherty S; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA., Janke AK; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Howard BN; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Suresh YP; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Ruprecht RM; Texas Biomedical Research Institute and Southwest National Primate Research Center, San Antonio, Texas, USA., Crowe JE Jr; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Carnahan RH; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Bailey JR; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Kanekiyo M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, Bethesda, Maryland, USA., Lingwood D; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunology, Duke University School of Medicine, Durham, North Carolina, USA., Moore PL; South African Medical Research Council Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Bonami RH; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Tomaras GD; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.; Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA., Archarya P; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA., Montefiori DC; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA., Kalams SA; Infectious Diseases Unit, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Lu S; Worcester HIV Vaccine, Worcester, Massachusetts, USA., Georgiev IS; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA.; Center for Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Source: Journal of virology [J Virol] 2025 Dec 23; Vol. 99 (12), pp. e0125625. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity.
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  Data: <searchLink fieldCode="AU" term="%22Jamieson+PJ%22">Jamieson PJ</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Abu-Shmais+AA%22">Abu-Shmais AA</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wasdin+PT%22">Wasdin PT</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Janowska+K%22">Janowska K</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+RJ%22">Edwards RJ</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Scapellato+G%22">Scapellato G</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Bukenya+M%22">Bukenya M</searchLink>; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.; Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Bass+LE%22">Bass LE</searchLink>; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+SI%22">Richardson SI</searchLink>; South African Medical Research Council Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Manamela+NP%22">Manamela NP</searchLink>; South African Medical Research Council Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Worcester HIV Vaccine, Worcester, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Barr+M%22">Barr M</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Adams+L%22">Adams L</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Paola+Velez-Castro+C%22">Paola Velez-Castro C</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+C%22">McCarthy C</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+CA%22">Alexander CA</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gillespie+RA%22">Gillespie RA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Mimms+J%22">Mimms J</searchLink>; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Suryadevara+N%22">Suryadevara N</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Sornberger+TA%22">Sornberger TA</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Zost+SJ%22">Zost SJ</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Parks+R%22">Parks R</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Flaherty+S%22">Flaherty S</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Janke+AK%22">Janke AK</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Howard+BN%22">Howard BN</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Suresh+YP%22">Suresh YP</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Ruprecht+RM%22">Ruprecht RM</searchLink>; Texas Biomedical Research Institute and Southwest National Primate Research Center, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Crowe+JE+Jr%22">Crowe JE Jr</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Carnahan+RH%22">Carnahan RH</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Bailey+JR%22">Bailey JR</searchLink>; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kanekiyo+M%22">Kanekiyo M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lingwood+D%22">Lingwood D</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Haynes+BF%22">Haynes BF</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Moore+PL%22">Moore PL</searchLink>; South African Medical Research Council Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Bonami+RH%22">Bonami RH</searchLink>; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Tomaras+GD%22">Tomaras GD</searchLink>; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.; Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Archarya+P%22">Archarya P</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Montefiori+DC%22">Montefiori DC</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Kalams+SA%22">Kalams SA</searchLink>; Infectious Diseases Unit, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; Worcester HIV Vaccine, Worcester, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Georgiev+IS%22">Georgiev IS</searchLink>; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA.; Center for Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
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