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A multicenter dose-defining/expansion phase 1b study of first-line regorafenib plus pembrolizumab in patients with advanced hepatocellular carcinoma.

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Title: A multicenter dose-defining/expansion phase 1b study of first-line regorafenib plus pembrolizumab in patients with advanced hepatocellular carcinoma.
Authors: El-Khoueiry AB; Division of Medical Oncology/Hematology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA., Kim RD; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA., Harris WP; Department of Medicine, University of Washington/Fred Hutchinson Cancer Center (FHCC), Seattle, Washington, USA., Sung MW; Division of Hematology and Oncology, Tisch Cancer Institute at Mount Sinai, New York, New York, USA., Waldschmidt D; Department of Gastroenterology and Hepatology, University Hospital Cologne, Cologne, Germany., Cabrera R; Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA., Garosi VL; Bayer S.p.A., Milan, Italy., Ploeger BA; Bayer AG, Berlin, Germany., Zebger-Gong H; Bayer AG, Berlin, Germany., Brennan BJ; Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, USA., Wang YA; Bayer HealthCare Pharmaceuticals, Cambridge, Massachusetts, USA., Mueller U; ClinStat GmbH, Huerth, Germany., Weispfenning A; Bayer AG, Berlin, Germany., Seidel H; Bayer AG, Berlin, Germany., Coppieters S; Bayer AG, Diegem, Belgium., Ishida TC; Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, USA., Galle PR; Department of Internal Medicine, Mainz University Medical Center, Mainz, Germany.
Source: Hepatology (Baltimore, Md.) [Hepatology] 2026 Jun 01; Vol. 83 (6), pp. 1433-1445. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A multicenter dose-defining/expansion phase 1b study of first-line regorafenib plus pembrolizumab in patients with advanced hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22El-Khoueiry+AB%22">El-Khoueiry AB</searchLink>; Division of Medical Oncology/Hematology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Kim+RD%22">Kim RD</searchLink>; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Harris+WP%22">Harris WP</searchLink>; Department of Medicine, University of Washington/Fred Hutchinson Cancer Center (FHCC), Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Sung+MW%22">Sung MW</searchLink>; Division of Hematology and Oncology, Tisch Cancer Institute at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Waldschmidt+D%22">Waldschmidt D</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Cabrera+R%22">Cabrera R</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Garosi+VL%22">Garosi VL</searchLink>; Bayer S.p.A., Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ploeger+BA%22">Ploeger BA</searchLink>; Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Zebger-Gong+H%22">Zebger-Gong H</searchLink>; Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Brennan+BJ%22">Brennan BJ</searchLink>; Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Wang+YA%22">Wang YA</searchLink>; Bayer HealthCare Pharmaceuticals, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+U%22">Mueller U</searchLink>; ClinStat GmbH, Huerth, Germany.<br /><searchLink fieldCode="AU" term="%22Weispfenning+A%22">Weispfenning A</searchLink>; Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Seidel+H%22">Seidel H</searchLink>; Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Coppieters+S%22">Coppieters S</searchLink>; Bayer AG, Diegem, Belgium.<br /><searchLink fieldCode="AU" term="%22Ishida+TC%22">Ishida TC</searchLink>; Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Galle+PR%22">Galle PR</searchLink>; Department of Internal Medicine, Mainz University Medical Center, Mainz, Germany.
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  Data: <searchLink fieldCode="JN" term="%228302946%22">Hepatology (Baltimore, Md.)</searchLink> [Hepatology] 2026 Jun 01; Vol. 83 (6), pp. 1433-1445. <i>Date of Electronic Publication: </i>2025 Nov 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+Inc%22">Wolters Kluwer Health, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8302946 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-3350 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202709139%22">02709139 </searchLink><i>NLM ISO Abbreviation: </i>Hepatology <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 01
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