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A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.

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Title: A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.
Authors: Smeland OB; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. o.b.smeland@medisin.uio.no., Kutrolli G; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Bahrami S; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; The Norwegian Association of Sheep and Goat Breeders (NSG), Ås, Norway., Fominykh V; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Parker N; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fuhrer J; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Hindley GFL; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.; Department of Psychiatry, Lovisenberg Diaconal Hospital, Oslo, Norway., Rødevand L; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Jaholkowski P; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Tesfaye M; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Parekh P; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Elvsåshagen T; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Department of Behavioural Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., Grotzinger AD; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA., Steen NE; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., van der Meer D; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., O'Connell KS; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Djurovic S; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway., Dale AM; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Department of Radiology, University of California, San Diego, La Jolla, CA, USA.; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, CA, USA., Shadrin AA; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Frei O; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway., Andreassen OA; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ole.andreassen@medisin.uio.no.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway. ole.andreassen@medisin.uio.no.
Source: Nature neuroscience [Nat Neurosci] 2025 Dec; Vol. 28 (12), pp. 2439-2450. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.
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  Data: <searchLink fieldCode="AU" term="%22Smeland+OB%22">Smeland OB</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. o.b.smeland@medisin.uio.no.<br /><searchLink fieldCode="AU" term="%22Kutrolli+G%22">Kutrolli G</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bahrami+S%22">Bahrami S</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; The Norwegian Association of Sheep and Goat Breeders (NSG), Ås, Norway.<br /><searchLink fieldCode="AU" term="%22Fominykh+V%22">Fominykh V</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Parker+N%22">Parker N</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Fuhrer+J%22">Fuhrer J</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Hindley+GFL%22">Hindley GFL</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.; Department of Psychiatry, Lovisenberg Diaconal Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Rødevand+L%22">Rødevand L</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Jaholkowski+P%22">Jaholkowski P</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Tesfaye+M%22">Tesfaye M</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Parekh+P%22">Parekh P</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Elvsåshagen+T%22">Elvsåshagen T</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Department of Behavioural Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Grotzinger+AD%22">Grotzinger AD</searchLink>; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Steen+NE%22">Steen NE</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22van+der+Meer+D%22">van der Meer D</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22O'Connell+KS%22">O'Connell KS</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Djurovic+S%22">Djurovic S</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Dale+AM%22">Dale AM</searchLink>; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Department of Radiology, University of California, San Diego, La Jolla, CA, USA.; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shadrin+AA%22">Shadrin AA</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Frei+O%22">Frei O</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ole.andreassen@medisin.uio.no.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway. ole.andreassen@medisin.uio.no.
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  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2025 Dec; Vol. 28 (12), pp. 2439-2450. <i>Date of Electronic Publication: </i>2025 Nov 11.
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