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Incorporation of 5-methylcytidine alleviates RIG-I-mediated innate immune responses to a self-amplifying RNA vaccine.

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Title: Incorporation of 5-methylcytidine alleviates RIG-I-mediated innate immune responses to a self-amplifying RNA vaccine.
Authors: Akahata W; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Komori M; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Morey AL; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Quiñones-Molina AA; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA., Hood JB; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA., Fofana J; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA., Romero L; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Peters E; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Webber JD; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Meeks T; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Przygonska PA; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Steinberg I; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Ober E; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Kim T; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Rogan DC; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Matsuda K; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Smith JF; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Gummuluru S; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA., Connors M; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Akiyama H; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Nov 12; Vol. 17 (824), pp. eadz2276. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Incorporation of 5-methylcytidine alleviates RIG-I-mediated innate immune responses to a self-amplifying RNA vaccine.
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  Data: <searchLink fieldCode="AU" term="%22Akahata+W%22">Akahata W</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Komori+M%22">Komori M</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Morey+AL%22">Morey AL</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Quiñones-Molina+AA%22">Quiñones-Molina AA</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Hood+JB%22">Hood JB</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Fofana+J%22">Fofana J</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Romero+L%22">Romero L</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Peters+E%22">Peters E</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Webber+JD%22">Webber JD</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Meeks+T%22">Meeks T</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Przygonska+PA%22">Przygonska PA</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Steinberg+I%22">Steinberg I</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ober+E%22">Ober E</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Kim+T%22">Kim T</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Rogan+DC%22">Rogan DC</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Matsuda+K%22">Matsuda K</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JF%22">Smith JF</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Gummuluru+S%22">Gummuluru S</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Connors+M%22">Connors M</searchLink>; HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Akiyama+H%22">Akiyama H</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Nov 12; Vol. 17 (824), pp. eadz2276. <i>Date of Electronic Publication: </i>2025 Nov 12.
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