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Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.

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Title: Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.
Authors: Younis S; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Moutusy SI; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Rasouli S; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Jahanbani S; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Pandit M; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Wu X; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Acharya S; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Sharpe O; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Wijeratne TU; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA., Harris ML; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA., Yang EY; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA., Chaichian Y; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA., Parsafar S; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA., Baker MC; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA., Harley JB; Research Service, US Department of Veterans Affairs Medical Center, Cincinnati, OH 45220, USA.; Cincinnati Education and Research for Veterans Foundation, Cincinnati, OH 45220, USA., Meffre E; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA., Steinman L; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.; Department of Pediatrics, Stanford University, Stanford, CA 94305, USA., Marshak-Rothstein A; Department of Medicine, University of Massachusetts School of Medicine, Worcester, MA 01655, USA., James JA; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Martinez OM; Department of Surgery, Stanford University, Stanford, CA 94305, USA., Utz PJ; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA 94305, USA., Orange DE; Rockefeller University, New York, NY 10065, USA.; Hospital for Special Surgery, New York, NY 10021, USA., Lanz TV; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA 94305, USA., Robinson WH; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.; Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA 94305, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Nov 12; Vol. 17 (824), pp. eady0210. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.
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  Data: <searchLink fieldCode="AU" term="%22Younis+S%22">Younis S</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Moutusy+SI%22">Moutusy SI</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Rasouli+S%22">Rasouli S</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Jahanbani+S%22">Jahanbani S</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Pandit+M%22">Pandit M</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Acharya+S%22">Acharya S</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Sharpe+O%22">Sharpe O</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Wijeratne+TU%22">Wijeratne TU</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Harris+ML%22">Harris ML</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Yang+EY%22">Yang EY</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Chaichian+Y%22">Chaichian Y</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Parsafar+S%22">Parsafar S</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Baker+MC%22">Baker MC</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Harley+JB%22">Harley JB</searchLink>; Research Service, US Department of Veterans Affairs Medical Center, Cincinnati, OH 45220, USA.; Cincinnati Education and Research for Veterans Foundation, Cincinnati, OH 45220, USA.<br /><searchLink fieldCode="AU" term="%22Meffre+E%22">Meffre E</searchLink>; Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Steinman+L%22">Steinman L</searchLink>; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.; Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Marshak-Rothstein+A%22">Marshak-Rothstein A</searchLink>; Department of Medicine, University of Massachusetts School of Medicine, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22James+JA%22">James JA</searchLink>; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+OM%22">Martinez OM</searchLink>; Department of Surgery, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Utz+PJ%22">Utz PJ</searchLink>; 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