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An unsupervised XAI framework for dementia detection with context enrichment.

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Title: An unsupervised XAI framework for dementia detection with context enrichment.
Authors: Singh D; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany. devesh.singh@med.uni-rostock.de.; Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Centre Rostock, Rostock, Germany. devesh.singh@med.uni-rostock.de., Brima Y; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany., Levin F; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany., Becker M; Institute for Visual and Analytic Computing, University of Rostock, Rostock, Germany., Hiller B; Institute for Visual and Analytic Computing, University of Rostock, Rostock, Germany., Hermann A; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology, University Hospital Rostock, Rostock, Germany., Villar-Munoz I; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany., Beichert L; Division Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany., Bernhardt A; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians- Universität (LMU) Munich, Munich, Germany., Buerger K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke & Dementia Research, University Hospital, LMU Munich, Munich, Germany., Butryn M; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute for Cognitive Neurology and Dementia Research, Faculty of Medicine, University Hospital Magdeburg, Magdeburg, Germany., Dechent P; MR-Research in Neurosciences, Department of Cognitive Neurology, University Medical Center Goettingen, Goettingen, Germany., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute for Cognitive Neurology and Dementia Research, Faculty of Medicine, University Hospital Magdeburg, Magdeburg, Germany., Ewers M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke & Dementia Research, University Hospital, LMU Munich, Munich, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany., Freiesleben SD; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Lindenberger Weg 80, 13125, Berlin, Germany., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute for Cognitive Neurology and Dementia Research, Faculty of Medicine, University Hospital Magdeburg, Magdeburg, Germany., Hetzer S; Berlin Center for Advanced Neuroimaging, Charité University Medicine Berlin, Berlin, Germany., Janowitz D; Institute for Stroke & Dementia Research, University Hospital, LMU Munich, Munich, Germany., Görß D; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kilimann I; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kimmich O; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research, Department of Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians- Universität (LMU) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Lohse A; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany., Luesebrink F; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Munk M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany., Perneczky R; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Ageing Epidemiology Research Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany., Preis L; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Lindenberger Weg 80, 13125, Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Munich, Germany.; University of Edinburgh and UK Dementia Research Institute, Edinburgh, United Kingdom.; German Center for Mental Health (DZPG), Munich, Germany., Prudlo J; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Neurology, University Medical Centre, Rostock, Germany., Prychynenko D; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany., Rauchmann BS; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Sheffield Institute for Translational Neuroscience, The University of Sheffield, Sheffield, United Kingdom.; Department of Neuroradiology, University Hospital, LMU Munich, Munich, Germany., Rostamzadeh A; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany., Roy-Kluth N; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany., Droste Zu Senden L; Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Lindenberger Weg 80, 13125, Berlin, Germany., Schott BH; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Magdeburg, Magdeburg, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University Hospital Bonn, Bonn, Germany., Synofzik M; Division Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Wiltfang J; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Faculty of Medicine, University of Cologne, Cologne, Germany., Weber MA; Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Centre Rostock, Rostock, Germany., Teipel SJ; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Dyrba M; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany. martin.dyrba@dzne.de.
Source: Scientific reports [Sci Rep] 2025 Nov 12; Vol. 15 (1), pp. 39554. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-025-26227-2