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Pravastatin for the prevention of recurrent hypertensive disorders of pregnancy: study protocol for a randomized, open-label, parallel-group, three-arm trial.

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Title: Pravastatin for the prevention of recurrent hypertensive disorders of pregnancy: study protocol for a randomized, open-label, parallel-group, three-arm trial.
Authors: Kumasawa K; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. kumasawak-gyn@h.u-tokyo.ac.jp., Kashiwabara K; Clinical Research Promotion Center, The University of Tokyo, Tokyo, Japan., Inoue M; Clinical Research Promotion Center, The University of Tokyo, Tokyo, Japan., Kaneko K; Division of Maternal Medicine, Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan., Hyodo H; Department of Obstetrics and Gynecology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan., Yamashita T; Department of Obstetrics and Gynecology, Aiiku Hospital, Tokyo, Japan., Iriyama T; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan., Nagamatsu T; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan., Sako M; Department of Clinical Research Promotion, Clinical Research Center, National Center for Child Health and Development, Tokyo, Japan., Kobayashi T; Department of Data Science, Clinical Research Center, National Center for Child Health and Development, Tokyo, Japan., Takahashi N; Department of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan., Saito S; University of Toyama, Toyama, Japan., Hirota Y; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan., Osuga Y; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.; Teikyo Academic Research Center, Teikyo University, Tokyo, Japan.; Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Tokyo, Japan.
Source: Trials [Trials] 2025 Nov 12; Vol. 26 (1), pp. 499. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pravastatin for the prevention of recurrent hypertensive disorders of pregnancy: study protocol for a randomized, open-label, parallel-group, three-arm trial.
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  Data: <searchLink fieldCode="AU" term="%22Kumasawa+K%22">Kumasawa K</searchLink>; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. kumasawak-gyn@h.u-tokyo.ac.jp.<br /><searchLink fieldCode="AU" term="%22Kashiwabara+K%22">Kashiwabara K</searchLink>; Clinical Research Promotion Center, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+M%22">Inoue M</searchLink>; Clinical Research Promotion Center, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+K%22">Kaneko K</searchLink>; Division of Maternal Medicine, Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hyodo+H%22">Hyodo H</searchLink>; Department of Obstetrics and Gynecology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+T%22">Yamashita T</searchLink>; Department of Obstetrics and Gynecology, Aiiku Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Iriyama+T%22">Iriyama T</searchLink>; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Nagamatsu+T%22">Nagamatsu T</searchLink>; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Sako+M%22">Sako M</searchLink>; Department of Clinical Research Promotion, Clinical Research Center, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+T%22">Kobayashi T</searchLink>; Department of Data Science, Clinical Research Center, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+N%22">Takahashi N</searchLink>; Department of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+S%22">Saito S</searchLink>; University of Toyama, Toyama, Japan.<br /><searchLink fieldCode="AU" term="%22Hirota+Y%22">Hirota Y</searchLink>; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Osuga+Y%22">Osuga Y</searchLink>; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.; Teikyo Academic Research Center, Teikyo University, Tokyo, Japan.; Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Tokyo, Japan.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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              Text: 2025 Nov 12
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