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Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression.

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Title: Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression.
Authors: Shorter JR; Department of Science and Environment, Roskilde University, Roskilde, Denmark. johnsh@ruc.dk., Pasman JA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands., Kurvits S; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Jangmo A; Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway., Naamanka J; SleepWell Research Program and Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Central Institute of Mental Health, Hector Institute for Artificial Intelligence in Psychiatry, Mannheim, Germany., Harder A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hagen E; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway., Kowalec K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Frilander N; SleepWell Research Program and Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Zetterberg R; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Copenhagen University Hospital, Roskilde, Denmark., Meijsen JJ; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Copenhagen University Hospital, Roskilde, Denmark.; Center for Eating and feeding Disorders Research, Mental Health Center Ballerup, Copenhagen University Hospital, Mental Health Services Copenhagen, Copenhagen, Denmark., Gådin JR; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Copenhagen University Hospital, Roskilde, Denmark., Bergstedt J; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Xiong Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hägg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Landén M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Rück C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Karolinska Institutet, Stockholm, Sweden., Wallert J; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Karolinska Institutet, Stockholm, Sweden., Skalkidou A; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Koch E; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway., Akdeniz BC; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway., Frei O; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway., Hovatta I; SleepWell Research Program and Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Reichborn-Kjennerud T; Department of Mental Health and Suicide, Norwegian Institute of Public Health, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Werge TM; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Copenhagen University Hospital, Roskilde, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Andreassen OA; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Tesli M; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.; Department of Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Psychiatry, Østfold Hospital, Grålum, Norway., Lehto K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Buil A; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Copenhagen University Hospital, Roskilde, Denmark., Lu Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. lu.yi@ki.se.
Corporate Authors: FinnGen
Source: Nature genetics [Nat Genet] 2025 Dec; Vol. 57 (12), pp. 2972-2979. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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