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Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.

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Title: Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.
Authors: Ling T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., O'Brien C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., St-Germain JR; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Rondeau V; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Shi M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Berman JM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Cepa A; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH., Saez Raez P; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.; Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH., Wunderlich M; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH., Carter KM; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH., Stillwell C; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH., Sexton C; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH., Culp-Hill R; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO., Reisz JA; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO., Adeel SA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Zeng AGX; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Bansal S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Tsao E; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Chen HT; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Dick JE; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Arruda A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Amaya ML; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO., Tikhonova AN; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Hope KJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Jones CL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH.; University of Cincinnati Cancer Center, Cincinnati, OH.
Source: Blood [Blood] 2026 Feb 19; Vol. 147 (8), pp. 863-876.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.
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  Data: <searchLink fieldCode="AU" term="%22Ling+T%22">Ling T</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22O'Brien+C%22">O'Brien C</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22St-Germain+JR%22">St-Germain JR</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rondeau+V%22">Rondeau V</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Berman+JM%22">Berman JM</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cepa+A%22">Cepa A</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Saez+Raez+P%22">Saez Raez P</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.; Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Wunderlich+M%22">Wunderlich M</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Carter+KM%22">Carter KM</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Stillwell+C%22">Stillwell C</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Sexton+C%22">Sexton C</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Culp-Hill+R%22">Culp-Hill R</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Reisz+JA%22">Reisz JA</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Adeel+SA%22">Adeel SA</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zeng+AGX%22">Zeng AGX</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bansal+S%22">Bansal S</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tsao+E%22">Tsao E</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+HT%22">Chen HT</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dick+JE%22">Dick JE</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Minden+MD%22">Minden MD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Arruda+A%22">Arruda A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Amaya+ML%22">Amaya ML</searchLink>; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Tikhonova+AN%22">Tikhonova AN</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hope+KJ%22">Hope KJ</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22D'Alessandro+A%22">D'Alessandro A</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Raught+B%22">Raught B</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jones+CL%22">Jones CL</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH.; University of Cincinnati Cancer Center, Cincinnati, OH.
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