The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents.
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| Title: | The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents. |
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| Authors: | Nadal-Gratacós N; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain., Puigseslloses P; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Guzmán L; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain., Weiss N; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain., Pottie E; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000, Ghent, Belgium., Riera-Colomer C; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain., Lardeux V; Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM, U-1084, Poitiers, France., Thiriet N; Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM, U-1084, Poitiers, France., Wang FH; Pronexus Analytical AB, Grindstuvägen 44, Bromma, 167 33, Stockholm, Sweden., Källsten L; Pronexus Analytical AB, Grindstuvägen 44, Bromma, 167 33, Stockholm, Sweden., Pérez-Esteban I; Unit of Research Psychobiology of Drug Dependence, Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Valencia, Spain., Ketsela G; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Margall J; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain., Berzosa X; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain., Pubill D; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain., Rodríguez-Arias M; Unit of Research Psychobiology of Drug Dependence, Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Valencia, Spain., Ettcheto M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Av. Josep Laporte, 2, 43204, Reus, Spain., Kehr J; Pronexus Analytical AB, Grindstuvägen 44, Bromma, 167 33, Stockholm, Sweden., Stove C; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000, Ghent, Belgium., Solinas M; Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM, U-1084, Poitiers, France., Sitte HH; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Vienna, Austria.; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, 19328, Amman, Jordan.; AddResS Centre for Addiction Research and Science, Medical University of Vienna, Vienna, Austria., Escubedo E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain., López-Arnau R; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu. |
| Source: | Molecular psychiatry [Mol Psychiatry] 2026 Apr; Vol. 31 (4), pp. 1909-1922. Date of Electronic Publication: 2025 Nov 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41238841 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nadal-Gratacós+N%22">Nadal-Gratacós N</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Puigseslloses+P%22">Puigseslloses P</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Guzmán+L%22">Guzmán L</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Weiss+N%22">Weiss N</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pottie+E%22">Pottie E</searchLink>; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Riera-Colomer+C%22">Riera-Colomer C</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lardeux+V%22">Lardeux V</searchLink>; Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM, U-1084, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Thiriet+N%22">Thiriet N</searchLink>; Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM, U-1084, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Wang+FH%22">Wang FH</searchLink>; Pronexus Analytical AB, Grindstuvägen 44, Bromma, 167 33, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Källsten+L%22">Källsten L</searchLink>; Pronexus Analytical AB, Grindstuvägen 44, Bromma, 167 33, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Pérez-Esteban+I%22">Pérez-Esteban I</searchLink>; Unit of Research Psychobiology of Drug Dependence, Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ketsela+G%22">Ketsela G</searchLink>; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Margall+J%22">Margall J</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Berzosa+X%22">Berzosa X</searchLink>; Chemical Reactions for Innovative Solutions (CRISOL), IQS School of Engineering, Universitat Ramon Llull, 08017, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pubill+D%22">Pubill D</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Arias+M%22">Rodríguez-Arias M</searchLink>; Unit of Research Psychobiology of Drug Dependence, Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ettcheto+M%22">Ettcheto M</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Av. Josep Laporte, 2, 43204, Reus, Spain.<br /><searchLink fieldCode="AU" term="%22Kehr+J%22">Kehr J</searchLink>; Pronexus Analytical AB, Grindstuvägen 44, Bromma, 167 33, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Stove+C%22">Stove C</searchLink>; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Solinas+M%22">Solinas M</searchLink>; Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM, U-1084, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Sitte+HH%22">Sitte HH</searchLink>; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Vienna, Austria.; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, 19328, Amman, Jordan.; AddResS Centre for Addiction Research and Science, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Escubedo+E%22">Escubedo E</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22López-Arnau+R%22">López-Arnau R</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu.; Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028, Barcelona, Spain. raullopezarnau@ub.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2026 Apr; Vol. 31 (4), pp. 1909-1922. <i>Date of Electronic Publication: </i>2025 Nov 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE |
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