Noninvasive Therapeutic Monitoring of Circulating Tumor DNA in BRAF-Mutant Metastatic Colon Cancer Using Droplet Digital PCR, Next-Generation Sequencing, and Fragmentomics.

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Title: Noninvasive Therapeutic Monitoring of Circulating Tumor DNA in BRAF-Mutant Metastatic Colon Cancer Using Droplet Digital PCR, Next-Generation Sequencing, and Fragmentomics.
Authors: Lam RCT; Faculty of Medicine, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Hui CWC; State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Shatin, Hong Kong.; Cancer Drug Testing Unit, Hong Kong Cancer Institute, Shatin, Hong Kong., Tse IOL; Department of Chemical Pathology, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Zhou Q; Department of Chemical Pathology, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.; Centre for Novostics, Hong Kong Science Park, Ma Liu Shui, Hong Kong.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Chow C; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Kang W; State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Shatin, Hong Kong.; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Chan KCA; State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Shatin, Hong Kong.; Department of Chemical Pathology, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.; Centre for Novostics, Hong Kong Science Park, Ma Liu Shui, Hong Kong.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Ma BBY; State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Shatin, Hong Kong.; Cancer Drug Testing Unit, Hong Kong Cancer Institute, Shatin, Hong Kong.; Department of Clinical Oncology, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Lam WKJ; State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Shatin, Hong Kong.; Department of Chemical Pathology, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.; Centre for Novostics, Hong Kong Science Park, Ma Liu Shui, Hong Kong.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
Source: Case reports in oncological medicine [Case Rep Oncol Med] 2025 Nov 07; Vol. 2025, pp. 8140524. Date of Electronic Publication: 2025 Nov 07 (Print Publication: 2025).
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101581035 Publication Model: eCollection Cited Medium: Print ISSN: 2090-6706 (Print) NLM ISO Abbreviation: Case Rep Oncol Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2090-6706
DOI:10.1155/crom/8140524