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RAF inhibitors activate the integrated stress response by direct activation of GCN2.

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Title: RAF inhibitors activate the integrated stress response by direct activation of GCN2.
Authors: Gilley R; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. becky.gilley@babraham.ac.uk., Kidger AM; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Andrew Kidger, Early Oncology R&D, AstraZeneca, Cambridge, UK., Neill G; Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, UK., Morrison E; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Severson P; Plexxikon Inc., 1 Bolivar Drive, Berkeley, CA, 94710, USA.; Paul Severson, Tupos Therapeutics, Inc., 25801 Industrial Blvd, Ste 100, Hayward, CA, 94545, USA., Byrne DP; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK., Kenneth NS; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK., Bollag G; Plexxikon Inc., 1 Bolivar Drive, Berkeley, CA, 94710, USA.; Chao Zhang, Tupos Therapeutics, Inc., 25801 Industrial Blvd Ste 100, Hayward, CA, 94545, USA., Zhang C; Plexxikon Inc., 1 Bolivar Drive, Berkeley, CA, 94710, USA.; Gideon Bollag, Opna Bio LLC, 600 Gateway Blvd, Ste 100, South San Francisco, CA, 94080, USA., Maia de Oliveira T; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Eyers PA; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK., Bayliss R; Astbury Centre for Structural Molecular Biology, School of Chemistry, University of Leeds, Leeds, UK., Masson GR; Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, UK., Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. simon.cook@babraham.ac.uk.
Source: Nature communications [Nat Commun] 2025 Nov 17; Vol. 16 (1), pp. 10033. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Gilley+R%22">Gilley R</searchLink>; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. becky.gilley@babraham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Kidger+AM%22">Kidger AM</searchLink>; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Andrew Kidger, Early Oncology R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Neill+G%22">Neill G</searchLink>; Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Morrison+E%22">Morrison E</searchLink>; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Severson+P%22">Severson P</searchLink>; Plexxikon Inc., 1 Bolivar Drive, Berkeley, CA, 94710, USA.; Paul Severson, Tupos Therapeutics, Inc., 25801 Industrial Blvd, Ste 100, Hayward, CA, 94545, USA.<br /><searchLink fieldCode="AU" term="%22Byrne+DP%22">Byrne DP</searchLink>; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.<br /><searchLink fieldCode="AU" term="%22Kenneth+NS%22">Kenneth NS</searchLink>; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.<br /><searchLink fieldCode="AU" term="%22Bollag+G%22">Bollag G</searchLink>; Plexxikon Inc., 1 Bolivar Drive, Berkeley, CA, 94710, USA.; Chao Zhang, Tupos Therapeutics, Inc., 25801 Industrial Blvd Ste 100, Hayward, CA, 94545, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Plexxikon Inc., 1 Bolivar Drive, Berkeley, CA, 94710, USA.; Gideon Bollag, Opna Bio LLC, 600 Gateway Blvd, Ste 100, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Maia+de+Oliveira+T%22">Maia de Oliveira T</searchLink>; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Eyers+PA%22">Eyers PA</searchLink>; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.<br /><searchLink fieldCode="AU" term="%22Bayliss+R%22">Bayliss R</searchLink>; Astbury Centre for Structural Molecular Biology, School of Chemistry, University of Leeds, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Masson+GR%22">Masson GR</searchLink>; Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Cook+SJ%22">Cook SJ</searchLink>; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. simon.cook@babraham.ac.uk.
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