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Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency.

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Title: Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency.
Authors: Pera J; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Programa de Doctorat de Medicina i Reserca Translacional, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), l'Hospitalet de Llobregat, Spain., Romero-Moya D; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain., Torralba-Sales E; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain., Andersson R; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Stem Cell Aging Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain., García-Hernández V; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, Hospital Del Mar Research Institute-Barcelona (HMRIB), Barcelona, Spain.; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK., Magallon-Mosella M; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain., Distefano M; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain., Berenguer Balaguer C; Endocrine Regulatory Genomics, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Castaño J; Hospital Sant Joan de Deu Advanced Therapies Platform, SJD Pediatric Cancer Center Barcelona (PCCB) building, Barcelona, Spain., De Giorgio F; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain., Qiu Z; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.; Programa de Doctorat en Biomedicina, Universitat de Barcelona, Barcelona, Spain., Iglesias A; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, Hospital Del Mar Research Institute-Barcelona (HMRIB), Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain., Spurk P; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Montserrat-Vazquez S; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Stem Cell Aging Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain., Pasquali L; Endocrine Regulatory Genomics, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Liang Z; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China., Català A; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Florian MC; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Stem Cell Aging Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; The Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Wlodarski MW; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Bigas A; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, Hospital Del Mar Research Institute-Barcelona (HMRIB), Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain., Marin-Bejar O; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain. omarin@igtp.cat.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain. omarin@igtp.cat.; Germans Trias i Pujol Health Science Research Institute (IGTP), Cancer Program, Badalona, Catalonia, Spain. omarin@igtp.cat., Giorgetti A; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain. agiorgetti@idibell.cat.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. agiorgetti@idibell.cat.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona University, Barcelona, Spain. agiorgetti@idibell.cat.; Fondazione Pisana Per la Scienza ONLUS (FPS), San Giuliano Terme, Italy. agiorgetti@idibell.cat.
Source: Nature communications [Nat Commun] 2025 Nov 17; Vol. 16 (1), pp. 10035. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency.
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  Data: <searchLink fieldCode="AU" term="%22Pera+J%22">Pera J</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Programa de Doctorat de Medicina i Reserca Translacional, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), l'Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Romero-Moya+D%22">Romero-Moya D</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Torralba-Sales+E%22">Torralba-Sales E</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Andersson+R%22">Andersson R</searchLink>; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Stem Cell Aging Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22García-Hernández+V%22">García-Hernández V</searchLink>; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, Hospital Del Mar Research Institute-Barcelona (HMRIB), Barcelona, Spain.; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Magallon-Mosella+M%22">Magallon-Mosella M</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Distefano+M%22">Distefano M</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Berenguer+Balaguer+C%22">Berenguer Balaguer C</searchLink>; Endocrine Regulatory Genomics, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castaño+J%22">Castaño J</searchLink>; Hospital Sant Joan de Deu Advanced Therapies Platform, SJD Pediatric Cancer Center Barcelona (PCCB) building, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22De+Giorgio+F%22">De Giorgio F</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Qiu+Z%22">Qiu Z</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.; Programa de Doctorat en Biomedicina, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias+A%22">Iglesias A</searchLink>; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, Hospital Del Mar Research Institute-Barcelona (HMRIB), Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Spurk+P%22">Spurk P</searchLink>; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Montserrat-Vazquez+S%22">Montserrat-Vazquez S</searchLink>; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Stem Cell Aging Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Pasquali+L%22">Pasquali L</searchLink>; Endocrine Regulatory Genomics, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Liang+Z%22">Liang Z</searchLink>; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Català+A%22">Català A</searchLink>; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Florian+MC%22">Florian MC</searchLink>; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain.; Stem Cell Aging Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; The Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wlodarski+MW%22">Wlodarski MW</searchLink>; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bigas+A%22">Bigas A</searchLink>; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, Hospital Del Mar Research Institute-Barcelona (HMRIB), Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Marin-Bejar+O%22">Marin-Bejar O</searchLink>; Hematopoietic Stem Cell Biology and Leukemogenesis, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Spain. omarin@igtp.cat.; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain. omarin@igtp.cat.; Germans Trias i Pujol Health Science Research Institute (IGTP), Cancer Program, Badalona, Catalonia, Spain. omarin@igtp.cat.<br /><searchLink fieldCode="AU" term="%22Giorgetti+A%22">Giorgetti A</searchLink>; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], Barcelona, Spain. agiorgetti@idibell.cat.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. agiorgetti@idibell.cat.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona University, Barcelona, Spain. agiorgetti@idibell.cat.; Fondazione Pisana Per la Scienza ONLUS (FPS), San Giuliano Terme, Italy. agiorgetti@idibell.cat.
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