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Synphilin-1 modulates alpha-synuclein assembly, release and uptake.

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Title: Synphilin-1 modulates alpha-synuclein assembly, release and uptake.
Authors: Lázaro DF; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA. diana.lazaro@pennmedicine.upenn.edu.; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany. diana.lazaro@pennmedicine.upenn.edu., Amen T; Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; School of Biological Sciences, University of Southampton, Southampton, UK., Gerhardt E; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany., Song C; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA., Burns R; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA., Kruse N; Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany., Santos PI; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany., Milovanovic D; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Einstein Center for Neuroscience, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany.; Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany., Höglinger G; Department of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Mollenhauer B; Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.; Paracelsus-Elena-Klinik, Kassel, Germany., Luk KC; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA., Lee VM; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA., Outeiro TF; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany. touteir@gwdg.de.; Max Planck Institute for Multidisciplinary Science, Göttingen, Germany. touteir@gwdg.de.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, UK. touteir@gwdg.de.; Scientific employee with an honorary contract at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany. touteir@gwdg.de.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Nov 20; Vol. 11 (1), pp. 326. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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  Data: Synphilin-1 modulates alpha-synuclein assembly, release and uptake.
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  Data: <searchLink fieldCode="AU" term="%22Lázaro+DF%22">Lázaro DF</searchLink>; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA. diana.lazaro@pennmedicine.upenn.edu.; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany. diana.lazaro@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Amen+T%22">Amen T</searchLink>; Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; School of Biological Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Gerhardt+E%22">Gerhardt E</searchLink>; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Song+C%22">Song C</searchLink>; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Burns+R%22">Burns R</searchLink>; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kruse+N%22">Kruse N</searchLink>; Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Santos+PI%22">Santos PI</searchLink>; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Milovanovic+D%22">Milovanovic D</searchLink>; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Einstein Center for Neuroscience, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany.; Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Höglinger+G%22">Höglinger G</searchLink>; Department of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mollenhauer+B%22">Mollenhauer B</searchLink>; Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.; Paracelsus-Elena-Klinik, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Luk+KC%22">Luk KC</searchLink>; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+VM%22">Lee VM</searchLink>; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Outeiro+TF%22">Outeiro TF</searchLink>; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany. touteir@gwdg.de.; Max Planck Institute for Multidisciplinary Science, Göttingen, Germany. touteir@gwdg.de.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, UK. touteir@gwdg.de.; Scientific employee with an honorary contract at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany. touteir@gwdg.de.
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