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Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration.

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Title: Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration.
Authors: Mukherjee S; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Velázquez Aponte RA; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Perry CE; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lee WD; Ludwig Institute for Cancer Research, Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.; Department of Biochemistry, Yonsei University, Seoul, South Korea., Janssen KA; Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Niere M; Department of Biomedicine, University of Bergen, Bergen, Norway., Adzika GK; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lu MJ; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Chan HR; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Zou X; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chen B; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bye N; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Xiao T; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Yook JS; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Salik O; Aging and Cardiovascular Discovery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Frederick DW; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gaspar RB; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Doan KV; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Davis JG; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rabinowitz JD; Ludwig Institute for Cancer Research, Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA., Wallace DC; Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Snyder NW; Aging and Cardiovascular Discovery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Kajimura S; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Cambronne XA; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Ziegler M; Department of Biomedicine, University of Bergen, Bergen, Norway., Baur JA; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. baur@pennmedicine.upenn.edu.
Source: Nature metabolism [Nat Metab] 2025 Dec; Vol. 7 (12), pp. 2424-2437. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: Hepatocyte mitochondrial NAD<superscript>+</superscript> content is limiting for liver regeneration.
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  Data: <searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Velázquez+Aponte+RA%22">Velázquez Aponte RA</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Perry+CE%22">Perry CE</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WD%22">Lee WD</searchLink>; Ludwig Institute for Cancer Research, Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.; Department of Biochemistry, Yonsei University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Janssen+KA%22">Janssen KA</searchLink>; Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Niere+M%22">Niere M</searchLink>; Department of Biomedicine, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Adzika+GK%22">Adzika GK</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+MJ%22">Lu MJ</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chan+HR%22">Chan HR</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zou+X%22">Zou X</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bye+N%22">Bye N</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+T%22">Xiao T</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yook+JS%22">Yook JS</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Salik+O%22">Salik O</searchLink>; Aging and Cardiovascular Discovery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Frederick+DW%22">Frederick DW</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gaspar+RB%22">Gaspar RB</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Doan+KV%22">Doan KV</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Davis+JG%22">Davis JG</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rabinowitz+JD%22">Rabinowitz JD</searchLink>; Ludwig Institute for Cancer Research, Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wallace+DC%22">Wallace DC</searchLink>; Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Snyder+NW%22">Snyder NW</searchLink>; Aging and Cardiovascular Discovery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kajimura+S%22">Kajimura S</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cambronne+XA%22">Cambronne XA</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ziegler+M%22">Ziegler M</searchLink>; Department of Biomedicine, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Baur+JA%22">Baur JA</searchLink>; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. baur@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%22101736592%22">Nature metabolism</searchLink> [Nat Metab] 2025 Dec; Vol. 7 (12), pp. 2424-2437. <i>Date of Electronic Publication: </i>2025 Nov 20.
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