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S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts.

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Title: S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts.
Authors: Zhao XY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Xu R; The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology (R.X.), Xi'an Jiaotong University, Shaanxi, China., Li JJ; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-J.L., P.-N.L., W.X.)., Chen YP; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Liu PN; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-J.L., P.-N.L., W.X.)., Yao JH; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-H.Y., Y.-W.H.)., Wang XP; Department of Cardiology, General Hospital of Central Theater Command, Wuhan, Hubei, China (X.-P.W.)., Hu YW; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-H.Y., Y.-W.H.)., Lou J; Key Laboratory of Aerospace Medicine of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China (J.L., X.Z.)., Xu F; Department of Orthopaedic Surgery, Honghui Hospital (F.X., Z.S.), Xi'an Jiaotong University, Shaanxi, China., She G; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Pang ZD; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Huang N; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Song Z; Department of Orthopaedic Surgery, Honghui Hospital (F.X., Z.S.), Xi'an Jiaotong University, Shaanxi, China., Deng XL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Du XJ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Zhang X; Key Laboratory of Aerospace Medicine of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China (J.L., X.Z.)., Zhang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.)., Xie W; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-J.L., P.-N.L., W.X.).
Source: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2026 Jan; Vol. 83 (1), pp. 87-102. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
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  Data: S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+XY%22">Zhao XY</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.).<br /><searchLink fieldCode="AU" term="%22Xu+R%22">Xu R</searchLink>; The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology (R.X.), Xi'an Jiaotong University, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Li+JJ%22">Li JJ</searchLink>; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-J.L., P.-N.L., W.X.).<br /><searchLink fieldCode="AU" term="%22Chen+YP%22">Chen YP</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.).<br /><searchLink fieldCode="AU" term="%22Liu+PN%22">Liu PN</searchLink>; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-J.L., P.-N.L., W.X.).<br /><searchLink fieldCode="AU" term="%22Yao+JH%22">Yao JH</searchLink>; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-H.Y., Y.-W.H.).<br /><searchLink fieldCode="AU" term="%22Wang+XP%22">Wang XP</searchLink>; Department of Cardiology, General Hospital of Central Theater Command, Wuhan, Hubei, China (X.-P.W.).<br /><searchLink fieldCode="AU" term="%22Hu+YW%22">Hu YW</searchLink>; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-H.Y., Y.-W.H.).<br /><searchLink fieldCode="AU" term="%22Lou+J%22">Lou J</searchLink>; Key Laboratory of Aerospace Medicine of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China (J.L., X.Z.).<br /><searchLink fieldCode="AU" term="%22Xu+F%22">Xu F</searchLink>; 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Department of Orthopaedic Surgery, Honghui Hospital (F.X., Z.S.), Xi'an Jiaotong University, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Deng+XL%22">Deng XL</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.).<br /><searchLink fieldCode="AU" term="%22Du+XJ%22">Du XJ</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.).<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Key Laboratory of Aerospace Medicine of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China (J.L., X.Z.).<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Shaanxi, China (X.-Y.Z., Y.-P.C., G.S., Z.-D.P., N.H., X.-L.D., X.-J.D., Y.Z.).<br /><searchLink fieldCode="AU" term="%22Xie+W%22">Xie W</searchLink>; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China (J.-J.L., P.-N.L., W.X.).
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  Data: <searchLink fieldCode="JN" term="%227906255%22">Hypertension (Dallas, Tex. : 1979)</searchLink> [Hypertension] 2026 Jan; Vol. 83 (1), pp. 87-102. <i>Date of Electronic Publication: </i>2025 Nov 21.
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