Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells.
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| Title: | Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells. |
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| Authors: | Li YR; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Bioengineering, University of California, Los Angeles, CA 90095., Shen X; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Bioengineering, University of California, Los Angeles, CA 90095., Zhu E; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Bioengineering, University of California, Los Angeles, CA 90095., Li Z; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Bioengineering, University of California, Los Angeles, CA 90095., Huang J; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Bioengineering, University of California, Los Angeles, CA 90095., Le T; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095., Tran C; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095., Radu CG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA 90095., Yang L; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.; Department of Bioengineering, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA 90095.; Eli and Edythe Broad Centre of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Molecular Biology Institute, University of California, Los Angeles, CA 90095.; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, CA 90095.; Goodman-Luskin Microbiome Center, University of California, Los Angeles, CA 90095. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 25; Vol. 122 (47), pp. e2517786122. Date of Electronic Publication: 2025 Nov 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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