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HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liver.

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Title: HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liver.
Authors: Edderkaoui M; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Medicine, UCLA, California, USA., Elmadbouh OHM; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA., Lim A; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Ou Y; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA., Hauptschein D; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Internal Medicine, Creighton University Health Education Alliance, Phoenix, AZ, USA., Guha A; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA., Darwish A; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Medicine, UCLA, California, USA., Calsavara VF; Cedars-Sinai Medical Center, Biostatistics Shared Resource, Department of Computational Biomedicine, Los Angeles, California, USA., Murali R; Department of Biomedical Sciences, Research Division of Immunology, CSMC, USA., Bhowmick N; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA., Osipov A; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA., Mathison AJ; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.; Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA., Urrutia R; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.; Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.; Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA., Wang Q; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA., Pandol SJ; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Medicine, UCLA, California, USA.
Source: International journal of biological sciences [Int J Biol Sci] 2025 Oct 24; Vol. 21 (15), pp. 6907-6925. Date of Electronic Publication: 2025 Oct 24 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
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  Data: HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liver.
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  Data: <searchLink fieldCode="AU" term="%22Edderkaoui+M%22">Edderkaoui M</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Medicine, UCLA, California, USA.<br /><searchLink fieldCode="AU" term="%22Elmadbouh+OHM%22">Elmadbouh OHM</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Lim+A%22">Lim A</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ou+Y%22">Ou Y</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Hauptschein+D%22">Hauptschein D</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Internal Medicine, Creighton University Health Education Alliance, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Guha+A%22">Guha A</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Darwish+A%22">Darwish A</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Medicine, UCLA, California, USA.<br /><searchLink fieldCode="AU" term="%22Calsavara+VF%22">Calsavara VF</searchLink>; Cedars-Sinai Medical Center, Biostatistics Shared Resource, Department of Computational Biomedicine, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Murali+R%22">Murali R</searchLink>; Department of Biomedical Sciences, Research Division of Immunology, CSMC, USA.<br /><searchLink fieldCode="AU" term="%22Bhowmick+N%22">Bhowmick N</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Osipov+A%22">Osipov A</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Mathison+AJ%22">Mathison AJ</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.; Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Urrutia+R%22">Urrutia R</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.; Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.; Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Pandol+SJ%22">Pandol SJ</searchLink>; Departments of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.; Department of Medicine, UCLA, California, USA.
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