Lead-in therapy targeting PD1 and/or LAG3 imposes distinct immune phenotypes in first-line treatment of metastatic melanoma.
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| Title: | Lead-in therapy targeting PD1 and/or LAG3 imposes distinct immune phenotypes in first-line treatment of metastatic melanoma. |
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| Authors: | Karapetyan L; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Cillo AR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Wang S; UPMC Hillman Cancer Center Biostatistics Facility, Pittsburgh, PA, USA., Karunamurthy A; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Massa RC; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA., Rohatgi A; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States; Alvin J. Siteman Cancer Center, St Louis, MO, USA., Deitrick C; UPMC Hillman Cancer Center Bioinformatics services, Pittsburgh, PA, USA., Najjar YG; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Davar D; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Luke JJ; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Sander C; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Kunning SR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Rose A; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bradley S; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Rush E; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Joy M; Translational pathology imaging laboratory, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Bao R; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center Bioinformatics services, Pittsburgh, PA, USA., Wang H; UPMC Hillman Cancer Center Biostatistics Facility, Pittsburgh, PA, USA., Vignali DAA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Co-senior authors., Bruno TC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Co-senior authors., Kirkwood JM; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Co-senior authors.; Lead contact. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2025 Nov 06. Date of Electronic Publication: 2025 Nov 06. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41282765 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lead-in therapy targeting PD1 and/or LAG3 imposes distinct immune phenotypes in first-line treatment of metastatic melanoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Karapetyan+L%22">Karapetyan L</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cillo+AR%22">Cillo AR</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; UPMC Hillman Cancer Center Biostatistics Facility, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Karunamurthy+A%22">Karunamurthy A</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Massa+RC%22">Massa RC</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rohatgi+A%22">Rohatgi A</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States; Alvin J. Siteman Cancer Center, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Deitrick+C%22">Deitrick C</searchLink>; UPMC Hillman Cancer Center Bioinformatics services, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Najjar+YG%22">Najjar YG</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Davar+D%22">Davar D</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Luke+JJ%22">Luke JJ</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sander+C%22">Sander C</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kunning+SR%22">Kunning SR</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rose+A%22">Rose A</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bradley+S%22">Bradley S</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rush+E%22">Rush E</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Joy+M%22">Joy M</searchLink>; Translational pathology imaging laboratory, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bao+R%22">Bao R</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center Bioinformatics services, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; UPMC Hillman Cancer Center Biostatistics Facility, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vignali+DAA%22">Vignali DAA</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Co-senior authors.<br /><searchLink fieldCode="AU" term="%22Bruno+TC%22">Bruno TC</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Co-senior authors.<br /><searchLink fieldCode="AU" term="%22Kirkwood+JM%22">Kirkwood JM</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Co-senior authors.; Lead contact. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2025 Nov 06. <i>Date of Electronic Publication: </i>2025 Nov 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41282765 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.11.04.25339499 Languages: – Code: eng Text: English Titles: – TitleFull: Lead-in therapy targeting PD1 and/or LAG3 imposes distinct immune phenotypes in first-line treatment of metastatic melanoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Karapetyan L – PersonEntity: Name: NameFull: Cillo AR – PersonEntity: Name: NameFull: Wang S – PersonEntity: Name: NameFull: Karunamurthy A – PersonEntity: Name: NameFull: Massa RC – PersonEntity: Name: NameFull: Rohatgi A – PersonEntity: Name: NameFull: Deitrick C – PersonEntity: Name: NameFull: Najjar YG – PersonEntity: Name: NameFull: Davar D – PersonEntity: Name: NameFull: Luke JJ – PersonEntity: Name: NameFull: Sander C – PersonEntity: Name: NameFull: Kunning SR – PersonEntity: Name: NameFull: Rose A – PersonEntity: Name: NameFull: Bradley S – PersonEntity: Name: NameFull: Rush E – PersonEntity: Name: NameFull: Joy M – PersonEntity: Name: NameFull: Bao R – PersonEntity: Name: NameFull: Wang H – PersonEntity: Name: NameFull: Vignali DAA – PersonEntity: Name: NameFull: Bruno TC – PersonEntity: Name: NameFull: Kirkwood JM IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 11 Text: 2025 Nov 06 Type: published Y: 2025 Titles: – TitleFull: MedRxiv : the preprint server for health sciences Type: main |
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