Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18-55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial.
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| Title: | Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18-55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial. |
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| Authors: | Chappell KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia., Mordant FL; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia., Amarilla AA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Liang B; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Li Z; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Lackenby JA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Jaberolansar N; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., O'Donnell J; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Kienzle V; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Kommajosyula V; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Tardiota N; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Bennet JK; Independent consultant, Melbourne, Victoria, Australia., Henderson CL; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Dalrymple RL; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Goh J; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Hoger K; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Gillard M; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Jones ML; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Hughes K; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Hughes B; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Barnes J; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Reading PC; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Ranasinghe C; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Subbarao K; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Munro TP; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia., Young PR; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia., Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia. |
| Source: | The Journal of infectious diseases [J Infect Dis] 2026 Feb 18; Vol. 233 (2), pp. e373-e382. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial |
| Journal Info: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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