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Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages.

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Title: Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages.
Authors: Hu HH; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Wang X; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Lan B; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Cheng H; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Wen H; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Chen F; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Wu J; Laboratory Animal Research Centre, Xiamen University, Xiamen, Fujian, China., Li M; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Chen J; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Zhang J; The Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, China., Chen D; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Lin S; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Lin J; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Yang M; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Wu Z; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Zheng ZZ; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Chen F; Department of Hepatobiliary Surgery, Xiamen Key Laboratory of Translational Medicine for Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China., Zhou J; Department of Hepatobiliary Surgery, Xiamen Key Laboratory of Translational Medicine for Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China., Chen G; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Chen Y; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China., Deng X; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China., Zhang CS; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. cszhang@xmu.edu.cn.; The Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, China. cszhang@xmu.edu.cn.; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China. cszhang@xmu.edu.cn., Liu J; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China. drjingfeng@fjmu.edu.cn., Lin SC; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. linsc@xmu.edu.cn.; The Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, China. linsc@xmu.edu.cn.; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China. linsc@xmu.edu.cn.
Source: Cell research [Cell Res] 2025 Dec; Vol. 35 (12), pp. 934-953. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages.
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  Data: <searchLink fieldCode="AU" term="%22Hu+HH%22">Hu HH</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Lan+B%22">Lan B</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Cheng+H%22">Cheng H</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Wen+H%22">Wen H</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Laboratory Animal Research Centre, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; The Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zheng+ZZ%22">Zheng ZZ</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Department of Hepatobiliary Surgery, Xiamen Key Laboratory of Translational Medicine for Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Hepatobiliary Surgery, Xiamen Key Laboratory of Translational Medicine for Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zhang+CS%22">Zhang CS</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. cszhang@xmu.edu.cn.; The Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, China. cszhang@xmu.edu.cn.; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China. cszhang@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China. drjingfeng@fjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lin+SC%22">Lin SC</searchLink>; State Key Laboratory of Cellular Stress Biology, State-Province Joint Engineering Research Center of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. linsc@xmu.edu.cn.; The Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, China. linsc@xmu.edu.cn.; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China. linsc@xmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229425763%22">Cell research</searchLink> [Cell Res] 2025 Dec; Vol. 35 (12), pp. 934-953. <i>Date of Electronic Publication: </i>2025 Nov 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9425763 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1748-7838 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210010602%22">10010602 </searchLink><i>NLM ISO Abbreviation: </i>Cell Res <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41422-025-01195-4
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