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Repeated ketamine exposure induces psychotic-like behaviors in mice via DRD1-mediated phosphorylation of p-Thr34 DARPP-32 and p-Ser10 histone H3.

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Title: Repeated ketamine exposure induces psychotic-like behaviors in mice via DRD1-mediated phosphorylation of p-Thr34 DARPP-32 and p-Ser10 histone H3.
Authors: Lv P; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Zhang J; Department of Pain, First Hospital of China Medical University, Shenyang, P.R. China., Wei JY; Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, P.R. China., Liu K; Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, P.R. China., Zhu XM; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Du Z; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Li A; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Zhang FT; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Lu Y; Key Laboratory of Health Ministry in Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, P.R. China. luy1@sj-hospital.org., Wu X; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China. xwu@cmu.edu.cn.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. xwu@cmu.edu.cn.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. xwu@cmu.edu.cn., Yao J; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China. yaojun198717@163.com.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. yaojun198717@163.com.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. yaojun198717@163.com.
Source: Cell biology and toxicology [Cell Biol Toxicol] 2025 Nov 25; Vol. 41 (1), pp. 153. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Repeated ketamine exposure induces psychotic-like behaviors in mice via DRD1-mediated phosphorylation of p-Thr34 DARPP-32 and p-Ser10 histone H3.
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  Data: <searchLink fieldCode="AU" term="%22Lv+P%22">Lv P</searchLink>; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Pain, First Hospital of China Medical University, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wei+JY%22">Wei JY</searchLink>; Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhu+XM%22">Zhu XM</searchLink>; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Du+Z%22">Du Z</searchLink>; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+FT%22">Zhang FT</searchLink>; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Key Laboratory of Health Ministry in Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, P.R. China. luy1@sj-hospital.org.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China. xwu@cmu.edu.cn.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. xwu@cmu.edu.cn.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. xwu@cmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenbei New District, Shenyang, 110122, P.R. China. yaojun198717@163.com.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. yaojun198717@163.com.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. yaojun198717@163.com.
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  Data: <searchLink fieldCode="JN" term="%228506639%22">Cell biology and toxicology</searchLink> [Cell Biol Toxicol] 2025 Nov 25; Vol. 41 (1), pp. 153. <i>Date of Electronic Publication: </i>2025 Nov 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>8506639 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-6822 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207422091%22">07422091 </searchLink><i>NLM ISO Abbreviation: </i>Cell Biol Toxicol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10565-025-10113-8
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      – TitleFull: Repeated ketamine exposure induces psychotic-like behaviors in mice via DRD1-mediated phosphorylation of p-Thr34 DARPP-32 and p-Ser10 histone H3.
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              Text: 2025 Nov 25
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