Safety and immunogenicity of a recombinant double-mutant heat-labile toxin derived from enterotoxigenic Escherichia coli in healthy Bangladeshi adults delivered by three different routes.

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Title: Safety and immunogenicity of a recombinant double-mutant heat-labile toxin derived from enterotoxigenic Escherichia coli in healthy Bangladeshi adults delivered by three different routes.
Authors: Bhuiyan TR; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Khanam F; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Basher SR; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Dash P; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Chowdhury MI; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Haque S; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Harun NB; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Akter A; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Karmakar PC; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Hakim A; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Amin S; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Kamruzzaman M; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Parvin N; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Ahmed T; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Butts J; The Emmes Company, LLC, Rockville, MD, United States., Pasetti MF; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States., Wahid R; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States., Sztein MB; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States., Maier N; PATH, Washington, DC, United States., White JA; PATH, Washington, DC, United States., Tomashek KM; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Bourgeois AL; PATH, Washington, DC, United States., Baqar S; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Kotloff KL; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States., Qadri F; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Chen WH; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Source: Frontiers in bacteriology [Front Bacteriol] 2025; Vol. 4. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9919033302406676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2813-6144 (Electronic) Linking ISSN: 28136144 NLM ISO Abbreviation: Front Bacteriol Subsets: PubMed not MEDLINE
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  Data: Safety and immunogenicity of a recombinant double-mutant heat-labile toxin derived from enterotoxigenic Escherichia coli in healthy Bangladeshi adults delivered by three different routes.
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  Data: <searchLink fieldCode="AU" term="%22Bhuiyan+TR%22">Bhuiyan TR</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Khanam+F%22">Khanam F</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Basher+SR%22">Basher SR</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Dash+P%22">Dash P</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Chowdhury+MI%22">Chowdhury MI</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Haque+S%22">Haque S</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Harun+NB%22">Harun NB</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Akter+A%22">Akter A</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Karmakar+PC%22">Karmakar PC</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Hakim+A%22">Hakim A</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Amin+S%22">Amin S</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Kamruzzaman+M%22">Kamruzzaman M</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Parvin+N%22">Parvin N</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Ahmed+T%22">Ahmed T</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Butts+J%22">Butts J</searchLink>; The Emmes Company, LLC, Rockville, MD, United States.<br /><searchLink fieldCode="AU" term="%22Pasetti+MF%22">Pasetti MF</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Wahid+R%22">Wahid R</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Sztein+MB%22">Sztein MB</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Maier+N%22">Maier N</searchLink>; PATH, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22White+JA%22">White JA</searchLink>; PATH, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Tomashek+KM%22">Tomashek KM</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Bourgeois+AL%22">Bourgeois AL</searchLink>; PATH, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Baqar+S%22">Baqar S</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Kotloff+KL%22">Kotloff KL</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Qadri+F%22">Qadri F</searchLink>; Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Chen+WH%22">Chen WH</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
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