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Cell-free BRAFV600E levels predict progression-free survival in children with Langerhans cell histiocytosis treated with dabrafenib and maintenance chemotherapy.

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Title: Cell-free BRAFV600E levels predict progression-free survival in children with Langerhans cell histiocytosis treated with dabrafenib and maintenance chemotherapy.
Authors: Cui L; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing., Wang D; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Zhao YZ; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Yao JF; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Wang CJ; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Zhao ZJ; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing., Li WJ; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing., Zhang Q; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing., Lian HY; ., Ma HH; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Ge J; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Fang ZS; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Wang WQ; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Dong JJ; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing., Wang TY; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing., Li ZG; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing. ericlzg70@hotmail.com., Zhang R; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing. ruizh1973@126.com.
Source: Haematologica [Haematologica] 2026 May 01; Vol. 111 (5), pp. 1786-1791. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Cell-free BRAF<superscript>V600E</superscript> levels predict progression-free survival in children with Langerhans cell histiocytosis treated with dabrafenib and maintenance chemotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Cui+L%22">Cui L</searchLink>; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Zhao+YZ%22">Zhao YZ</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Yao+JF%22">Yao JF</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Wang+CJ%22">Wang CJ</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Zhao+ZJ%22">Zhao ZJ</searchLink>; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing.<br /><searchLink fieldCode="AU" term="%22Li+WJ%22">Li WJ</searchLink>; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing.<br /><searchLink fieldCode="AU" term="%22Lian+HY%22">Lian HY</searchLink>; .<br /><searchLink fieldCode="AU" term="%22Ma+HH%22">Ma HH</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Ge+J%22">Ge J</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Fang+ZS%22">Fang ZS</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Wang+WQ%22">Wang WQ</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Dong+JJ%22">Dong JJ</searchLink>; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing.<br /><searchLink fieldCode="AU" term="%22Li+ZG%22">Li ZG</searchLink>; Laboratory of Hematologic Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Childrens Health, Beijing, China; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing. ericlzg70@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; National Key Discipline of Pediatrics, Capital Medical University, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China; Department of Hematology, Hematology center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing. ruizh1973@126.com.
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  Data: <searchLink fieldCode="JN" term="%220417435%22">Haematologica</searchLink> [Haematologica] 2026 May 01; Vol. 111 (5), pp. 1786-1791. <i>Date of Electronic Publication: </i>2025 Nov 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.3324/haematol.2025.287578
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        Text: English
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      – TitleFull: Cell-free BRAFV600E levels predict progression-free survival in children with Langerhans cell histiocytosis treated with dabrafenib and maintenance chemotherapy.
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